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Harnish CR, RT Sabo, DM Morries, EO Acevedo

Comparison of Two Different Sprint Interval Work to Rest Ratios on Acute Metabolic and Inflammatory Responses. Harnish CR, RT Sabo, DM Morries, EO Acevedo. This research was made possible through the support of Award Number UL1RR031990 from the National Center for Research Resources. Motor Unit

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Harnish CR, RT Sabo, DM Morries, EO Acevedo

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  1. Comparison of Two Different Sprint Interval Work to Rest Ratios on Acute Metabolic and Inflammatory Responses Harnish CR, RT Sabo, DM Morries, EO Acevedo This research was made possible through the support of Award Number UL1RR031990 from the National Center for Research Resources

  2. Motor Unit Recruitment IL-6 ↑[Cai2+] IL-6 ↓Glycogen AMPK RECOVERY IL-6 Functional GLUT-4 ↑Glucose Uptake Cell Translocation IL-6 IL-6 Inactive GLUT-4 IL-6 TNF-α IL-10 IL-6 ↑Lypolysis Insulin AMPK Stimulation Inhibition From Cytokines to Myokines ↑Si or Glucose Uptake Initiation of muscle-derived IL-6 release and the subsequent cascade effect Adapted from Febbraio and Pedersen 2002; Pedersen and Fischer 2007

  3. Sprint Interval Training • 6 weeks 30 sec Wingate sprints elicited similar adaptations to endurance • Weekly volume 225 vs 2250 kJ/wk • Increased enzymes and mitochondria Burgomaster, 2008; Gibala, 2006, 2008, 2009 2 weeks SIT enhanced Si and metabolic function Babraj, 2009; Gibala 2011; Little 2012 Inconclusive single session data on Si or Cytokines Brestoff et al.2010 showed no acute impact of 5 sprints, raising questions about mechanism for chronic improvement Work to rest ratio believed to impact exercise-stress response Note: Only 8 of 12 subjects could be analyzed for cytokine response.

  4. Questions Is there a relationship between inflammation and Si? Will shorter rests influence either inflammation or Si?

  5. Methods 13 Men & 2 women 23.8 (0.9) yrs, 78.5 (1.6) kg, 1.8 (0.27) m 16.9 (1.7) % fat 237 (14.6) 2 min Max Watts Testing completed over 3 – 4 wk; 0700-1100 hrs 12 hr fast Each subject completed both sprint sessions Tabata: 10X 20 sec sprint with 10 sec recovery – 5% Wingate: 5X 30 sec sprint with 4 min rest – 7%

  6. PRE BLOOD POST BLOOD 24 hr POST BLOOD 1 hr POST BLOOD Study Design

  7. RESULTS Inflammatory response to Tabata and Wingate * Significant p < 0.05; 2X4 ANOVA

  8. RESULTS Insulin Sensitivity before and after SIT p < 0.03 p < 0.67 Mg*I2*mM-1*mU-1*min-1 PRE TABATA WINGATE Cederholm Index for peripheral insulin sensitivity, 1990

  9. Conclusions W:R does not affect SIT inflammatory response Data indicate IL-10 and TNF myokines Single SIT session does not improve Insulin Sensitivity 24 hrs post exercise SIT Pro-inflammatory? Increased IL-10 ineffective at improving Si Future Work: When does Si begin to improve after SIT? Between 1 day & 14 days?

  10. Special Thanks Shirley Helm VCU CCTR and CRSU Staff Dept of Health & Human Performance Experiment.com

  11. RESULTS Pearson Correlation: TNF-α vs IL-10 IL-10 R= 0.79 p < 0.0001 TNF-α

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