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Osteoscoop - Issue N°298 – July 2013

Parathyroid hormone (1-34) counteracts the glucocorticoid-induced suppression of Interleukin-11 in osteoblasts. Osteoscoop - Issue N°298 – July 2013. Mature osteoblasts. Preosteoblasts. + Glucocorticoid excess (GC). IL-11. Low bone formation. Low osteoblast maturation

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Osteoscoop - Issue N°298 – July 2013

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  1. Parathyroid hormone (1-34) counteracts the glucocorticoid-induced suppression of Interleukin-11 in osteoblasts Osteoscoop - Issue N°298 – July 2013

  2. Mature osteoblasts Preosteoblasts + Glucocorticoidexcess (GC) IL-11 Lowbone formation Lowosteoblast maturation High osteoblastapoptosis Low IL-11 expression

  3. Mature osteoblasts Preosteoblasts + Glucocorticoidexcess (GC) IL-11 Lowbone formation Lowosteoblast maturation High osteoblastapoptosis Low IL-11 expression GC + PTH(1-34) FosB DFosB Higherbone formation IL-11 Osteoblast maturation Osteoblastapoptosis Higher IL-11 expression

  4. Mature osteoblasts Preosteoblasts + Glucocorticoidexcess (GC) IL-11 Lowbone formation Lowosteoblast maturation High osteoblastapoptosis Low IL-11 expression GC + PTH(1-34) FosB DFosB Higherbone formation IL-11 Osteoblast maturation Osteoblastapoptosis Higher IL-11 expression PTH(1-34) GC Pkcd DFosB DFosB JunD JunD GR Smad1 Smad1 P P IL-11 Nucleus

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