Welcome to the Molecular Medicine course!

1. Welcome to theMolecular Medicinecourse!

2. Registration • General information • Over-arching goals • Roll call • Course contents • Information about KS library • Coffee • Course evaluation HT 2009 • Study design (research application) • Seminar assignment • Final examination • Study visit • Molecular Medicine - from bed to bench

3. Course leader: Rachel Fisher 08-517 732 45 rachel.fisher@ki.se Deputy course leader: Ewa Ehrenborg 08-517 761 91 ewa.ehrenborg@ki.se Teaching assistant: Louisa Cheung 08-517 732 21 louisa.cheung@ki.se Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, L8:02 Course secretary: Sofia Asp Department of Medicine, Unit for Internal Medicine, Karolinska University Hospital, A3:02 08-517 716 33 sofia.asp@ki.se Office hours daily 9.00am - 3.00pm

4. Over-arching goals • To integrate previously gained knowledge • To stimulate team work • To analyse, evaluate and interpret raw data • To design a study and write a research application • To provide “real life” experience

5. Roll call

6. Course set up • Lectures usually 9am – 3pm (check venue!) • Labs/demonstrations/seminars usually in groups • Time scheduled for group work • Seminar assignment • Presentation of group work (research application) near end of course • Study visit to AstraZeneca • Revision time (last timetabled activity 17th Dec) • Final written examination: 12th January

7. Course contents (15 hp/ECTS) • Specific areas • Circulation, Ischemia, Metabolic Syndrome, Diabetes 4 w • Gastroenterology 1 w • Endocrinology 1 w • Respiration, asthma & allergy 1 w • Pathology 1 w • Clin immunology/Clin chemistry 1 w • 9 w • Assignments etc. • Molecular biology lab (incl. inter-professional experience) • Seminars • Research application • Study visit • Seminar assignment • Revision Integrated

8. Course literature • Text books from previous courses: physiology, pharmacology, biochemistry, molecular genetics, immunology • Articles and links on the web page • Lecture summary points (from lecturers)

9. Information about KS libraryBarbro Wiström

10. Seminar assignment Lab “Methods in Molecular Biology” Lectures, demos, labs, exam Pathology seminars Research plan

11. Labs and Demonstrations • Lab: “Methods in Molecular Biology – Theory and Practice” • (3/11, 16-18/11, 23-25/11, 30/11-2/12, 7/12 (statistics), 10/12) • Angiography demonstration (15/11) • Lung/allergy demonstration (9/11) • Blood grouping lab (8-9/12)

12. Labs • You must bring your own lab coats! • Some labs and demonstrations will be performed in active research labs- show consideration for those who work there

13. Pathology seminars • Pathology integrated into the course • 3 seminars: Atherosclerosis (17-19/11) Endocrinology (24-26/11) Gastrointestinal (1-3/12) • At HuddingeTeacher-led session (10 - 11am)Self-study (11am – 12noon, 1 - 2pm)Review with teacher (2 - 3pm)

14. Coffee

15. Course evaluation HT 2009 Good • Research application • Lab “Methods in Molecular Biology” • AstraZeneca, Göteborg • Course leaders/administration Mixed • Clinical emphasis • Pathology seminars • Written assignment • Lecturers Bad • Lack of a course text book • Some repetition within lectures • Too many lectures

16. New for HT 2010 • Many lectures removed • Seminar assignment (replace written assignment) • New Pathology seminar (GI) • Modified data analysis of Lab “Methods in Molecular Biology” • Spread work load more evenly over course • Lighter schedule at end of course to allow time for revision

17. Evaluation of the course • We rely on your feedback to improve the course • Please give constructive feedback • Evaluation forms (online) • Cinema ticket voucher if all evaluation forms completed + submitted! • Course councils • with representatives 29/11 • with whole class 16/12

18. Forms of feedback reviewing progress with  students Research application feedback on assignments & exam editing and redrafting  Methods in mol biol Pre-submission guidance and feedback  Research application feedforward assignments  Research application Informing about feedback whole-class feedback  Methods in mol biol

19. Course language • All literature in English • Lectures in English • All assignments may be written in either English or Swedish

20. Research application • Group assignment • Choose a specific issue to focus on • Design a research project • Write a research application • Present the project orally • Answer questions • Team work • Realistic exercise

21. Research application:groups and topics • Groups 1-6 each split in 2 • 12 ”subgroups” of 3-4 people • Each subgroup allocated a broad topic • Detailed project chosen by the subgroup • Discussions with and feed back from topic ”mentor”

22. Inflammation in cardiovascular disease Transcription factor regulation in inflammation Aneurysm Energy metabolism (endocrinology) Allergy Diabetes and co-morbidities Metabolism and cardiovascular disease Mesenchymal stem cells and bone formation Asthma Thrombosis and haemostasis Liver Proteoglycans and cardiovascular disease Research application – broad topics 2 topics/group, 3-4 people/research application

23. Research applicationtopic lottery

24. Seminar assignment • Handed out at course start • Group work / individual assessment • Research based aspects, requires independent work • Grading = pass / fail • Replaces “Written Assignment”

25. Examination • Final examination: Wednesday 12 January Grades A-F • Questions testing knowledge + understanding

26. Grading of the examination • F, Fx, E, D, C, B, A • Goal-based assessment • Evaluating the level of knowledge obtained NOT the amount of knowledge • F, Fx = fail • E = basic pass: identify, describe, list • C, D = pass with merit: compare, explain connections, analyse, apply • B, A = pass with distinction: theorise, hypothesise, reflect

27. One relevant aspect Several relevant independent aspects Integrated into a structure Generalized to new domain Extended abstract B, A Relational C, D Prestructural F Multistructural E Unistructural Fx

28. To pass the course … • The student must obtain a grade of at least E for the written examination (5 hp) • The student must also pass • the seminar assignment (3 hp) • the research application (3 hp) • all labs, demonstrations, seminars (4 hp)

29. Replacement assignments • When compulsory parts of the course are missed, there are replacement exercises • If written, these must be handed in by the last day of the course (14 January 2011) • Next opportunity for submission = next course (HT2011)

30. AstraZeneca, Göteborg • Coach journey Thursday 13/1, 10.00am • Eat dinner together • Study visit Friday 14/1, 8.30am – 3.30pm • Information + presentations • Guided tour of labs • Return journey, depart around 3.30pm • Contribution of 250kr/person

31. Information about Masters Programme • 6th December, 3pm • Medicine Lecture Theatre (A6:04) • Dan Grandér

32. Molecular Medicine:from bed to bench • Important clinical contact • Translational research • Cross-disciplinary • “From bench to bed and back again”

33. Please use the web page!