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Lecture 7

Lecture 7. More of the Citric Acid Cycle. Regulation of the Citric Acid Cycle. P. i. E. -OH. 1. pyruvate. pyruvate. dehydrognase. dehydrogenase. kinase. phosphatase. 2-. E. -OPO. H. O. 1. 3. 2. Regulation of the pyruvate dehydrogenase complex. Protein modification. ATP.

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Lecture 7

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  1. Lecture 7 More of the Citric Acid Cycle

  2. Regulation of the Citric Acid Cycle

  3. P i E -OH 1 pyruvate pyruvate dehydrognase dehydrogenase kinase phosphatase 2- E -OPO H O 1 3 2 Regulation of the pyruvate dehydrogenase complex • Protein modification ATP active ADP inactive insulin

  4. Compare the amino acid and the a-keto acid - Transaminase oxaloacetate aspartate

  5. Replenishment of Krebs Cycle In mammalian tissue

  6. OH O enol keto C C NH NH HN N H N S Avidin in egg white O binds to biotin Biotin Lysine of enzyme Biotin: Carboxylating Agent

  7. P i O ADP H C NH N O O O P O C OH S Biotin in Pyruvate Carboxylase ATP O

  8. Biotin in Pyruvate Carboxylase Carboxybiotinyl-enzyme

  9. Biotin in Pyruvate Carboxylase

  10. Anaplerotic Reactions Reactions that replenish the intermediates of the Krebs cycle

  11. phe, tyr, leu, lys, trp, ile Krebs cycle F umarate -KG a S uccinate Why replenishment is necessary Pyruvate Acetyl-CoA asn, asp Citrate OAA glu, pro, gln porphyrins heme, chlorophyll

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