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GnRH-II R. GnRH-I R. RPTK. SOS. RAS. RAF. P. GRB 2. Gq. Gi. (A). (E). (C). (B). PTP. MAPK-K. P. (D). p50 p65. EGF receptor mRNA expression. I k B. MAPK. P. ?. I k B. JNK / c-Jun. JunD. p50 p65. P. MAPK. c-fos expression. apoptosis. cell proliferation. TCF.
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GnRH-II R GnRH-I R RPTK SOS RAS RAF P GRB2 Gq Gi (A) (E) (C) (B) PTP MAPK-K P (D) p50 p65 EGF receptor mRNA expression IkB MAPK P ? IkB JNK / c-Jun JunD p50 p65 P MAPK c-fos expression apoptosis cell proliferation TCF P AP-1 cell cycle DNA synthesis
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