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Understanding PPARs: Mechanisms, Functions, and Their Role in Disease

This article explores Peroxisome Proliferator-Activated Receptors (PPARs), focusing on their activation functions (AF1, AF2), structural domains (DBD, LBD), and mechanisms of transcriptional regulation. We discuss the role of PPAR isotypes in lipid transport and metabolic processes influenced by fibrates and glitazones. Additionally, we examine the interactions with cytokines, such as Fos and Jun, and the implications of PPARs in disease from biochemical and physiological perspectives. The discussion highlights the influence of various factors on PPAR activity, offering insights into therapeutic potential.

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Understanding PPARs: Mechanisms, Functions, and Their Role in Disease

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  1. PPARs(Peroxisome proliferator activated receptor) Jun- su Park

  2. PPARs AF1 DBD Hinge LBD AF2 N C A/B C D E/F Activation Function 1 Transactivation Activation Function 2 Transactivation DNA-binding domain Ligand-binding domain

  3. PPARs

  4. Mechanisms of transcription Fibrates, glitazones, fatty acid derivatives Cytokines cytokines Fos p50 p65 Jun PPAR Jun p65 Fos p50 PPAR RXR GGGGACTTTCCC AGGTCANAGGTCA TGAGTCA Nucleus

  5. Expression and functions of the three PPARisotypes. fibrates TZDs

  6. Lipid transport in the blood(lipoproteins) PPRE

  7. The compound to make PPAR-alpha activate.

  8. The compound to make PPAR-gamma activate.

  9. PDB ID:IKKQ

  10. The conclusion and discussion. ㅁFunctions of the PPARs ㅁThe relation of PPARs and the disease. (Through the immunity viewpoint and biochemisty, physiology) ㅁVarious Factor which participates in PPARs.

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