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Valentina Liakina , Danut ė Speičienė Algimantas Irnius, Jonas Valantinas

Changes in hepatitis C virus infection routes and genotype s distribution in chronic hepatitis C cohort of Lithuania. Valentina Liakina , Danut ė Speičienė Algimantas Irnius, Jonas Valantinas Centre of Hepatology, Gastroenterology and Dietetics Faculty of Medicine, Vilnius University.

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Valentina Liakina , Danut ė Speičienė Algimantas Irnius, Jonas Valantinas

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  1. Changes in hepatitis C virus infection routes and genotypes distribution in chronic hepatitis C cohort of Lithuania Valentina Liakina, Danutė Speičienė Algimantas Irnius, Jonas Valantinas Centre of Hepatology, Gastroenterology and Dietetics Faculty of Medicine, Vilnius University

  2. Chronic hepatitis C cohort From 1996 to 2006 about 2000 chronic hepatitis C patients were admitted for antiviral treatment at the Center of Hepatology, Gastroenterology and Dietetics of Vilnius University Hospital Santariškių Klinikos. 1158 patients (638 males and 520 females; age range, 16-80 years; mean age, 48.7±13.0 years) were enrolled into the study of HCV infection routes. Anonymous questionnaire with the list of possible infection routes was proposed to the participants. Data were published in Medical Science Monitor 2009

  3. Genotypes distribution in chronic hepatitis C patients Patients Age groups

  4. Subtypes distribution in chronic hepatitis C patients

  5. Analysis of chronic hepatitis C patients with a single risk factor for HCV acquisition

  6. Multivariate analysis of HCV risk factors depending on the age of patients LMH, Long or multiple hospitalizations; CHC in family, Chronic hepatitis C in a family member. *An independent risk factor not confirmed by multivariate logistic regression analysis.

  7. Multivariate analysis of hepatitis C virus risk factors depending onthe gender LMH, Long or multiple hospitalizations. *An independent risk factor not confirmed by multivariate logistic regression analysis.

  8. Risk factors for hepatitis C virus acquisition and genotypes

  9. Conclusions • In our population HCV genotype 1 (subtype 1b) prevails – more than 70%, genotype 3 – about 30% and few genotype 2. • Genotype 1 mostly spreads nosocomialy, genotype 3 - through intravenous drug use. • Nosocomial HCV transmission is well controlled and the main recent infection route is intravenous drug use. • The shift in HCV transmission pathways predetermined the shift in HCV genotypes from 1 to 3. • The safety of blood and blood products transfusions strongly depend on NAT sensitivity and still is a worldwide problem, especially in case of paid donations. • Despite control of nosocomial HCV spread we can not expect a decrease of HCV infected persons due infection spread through less controlled IDU route. • Interplay between HCV spread lowering and increasing factors will determine the status of infection in our and other European countries.

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