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WBC Disorders

Lecture plan. Normal PathologyWhite cell disordersNon ? neoplastic Abnormalities ?in

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WBC Disorders

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    1. WBC Disorders

    2. Lecture plan Normal Pathology White cell disorders Non neoplastic Abnormalities ?in # - Penias & ? - Philias Neoplastic disorders Premalignant conditions Myelodysplastic syndromes Myeloproliferative disorders Malignant or Leukemias Acute & Chronic Myeloid & Lymphoid Hairy cell leukemia Plasma cell neoplasms

    3. Lecture plan Lymph node disorders Non neoplastic or Inflammatory Acute Lymphadenitis Chronic Lymphadenitis Neoplastic or Lymphomas Hodgkins lymphoma Non- Hodgkins Lymphoma Miscellaneous Langerhans cell Histiocytosis Splenic disorders Disorders of thymus

    4. Lecture plan Normal Pathology White cell disorders Non neoplastic Abnormalities ?in # - Penias & ? - Philias Neoplastic disorders Premalignant conditions Myelodysplastic syndromes Myeloproliferative disorders Malignant or Leukemias Acute & Chronic Myeloid & Lymphoid Hairy cell leukemia Plasma cell neoplasms

    5. WBC- Normal Total Leukocyte count Differential Leukocyte count Basic functions of Leukocytes

    6. WBC - CBC

    7. Lecture plan Normal Pathology White cell disorders Non neoplastic Abnormalities ?in # - Penias & ? - Philias Neoplastic disorders Premalignant conditions Myelodysplastic syndromes Myeloproliferative disorders Malignant or Leukemias Acute & Chronic Myeloid & Lymphoid Hairy cell leukemia Plasma cell neoplasms

    8. WBC :Non neoplastic Abnormalities Penias (Leukopenia) Neutropenia is most common and important low circulating neutrophil count <1500 cell/cu. mm Neutropenia 1000 cells/ cu. mm worrisome 500 cells/ cu. mm - serious infections 100 cells/ cu. mm - life threatening ( also called agranulocytosis)

    9. WBC :Non neoplastic Abnormalities Penias (Neutropenia) Causes ? or ineffective production Aplastic anemia Drugs Disorders Vit. deficiencies ( B12, Folate) Myelodysplastic syndromes Inherited disorder kostmann syndrome (defective genes of granulocyte differentiation) ? removal from circulation Immunological SLE, Drugs Hypersplenism ?utilization infections ( mainly Bacterial)

    10. WBC :Non neoplastic Abnormalities Neutropenia Most significant cause Drugs May dose related or Idiosyncratic Act by marrow suppression (chlorpromazine) or immunological (sulfa & Thiouracil) Morphology = marrow changes depend on underlying cause Hyperplasia of marrow if the cause is peripheral destruction or ineffective poiesis Hypoplasia if it is due to Myelo- suppression

    11. Lecture plan Normal Pathology White cell disorders Non neoplastic Abnormalities ?in # - Penias & ? #- Philias Neoplastic disorders Premalignant conditions Myelodysplastic syndromes Myeloproliferative disorders Malignant or Leukemias Acute & Chronic Myeloid & Lymphoid Hairy cell leukemia Plasma cell neoplasms

    12. WBC :Non neoplastic Abnormalities Leukocytosis Leukocytosis Philias ( Example Neutrophilia) Pathogenesis Precursor pool ? storage pool ?peripheral blood (Margination & circulating) ? Tissue pool Mechanisms For Neutrophils ***Mostly from marrow storage pool immediate Granulocytopoiesis from stimulation of marrow stem cells by inflammatory mediators (IL-1, TNFa) For Eosinophils- IL-5 For Lympho IL-7

    13. WBC :Non neoplastic Abnormalities Leukocytosis - Neutrophilia

    14. WBC :Non neoplastic Abnormalities Leukocytosis Morphology ?# neutrophils &Toxic granulations ( abnormal azuriphilic granules), Dhole bodies (Endoplasmic Reticulum) like in Kawasakis disease) Differential Diagnosis Leukemoid reaction (inflammation) from leukemia

    15. WBC :Non neoplastic Abnormalities Leukocytosis -Toxic Granulation:

    16. WBC :Non neoplastic Abnormalities Leukocytosis - causes

    17. WBC :Non neoplastic Abnormalities Leukocytosis -Lymphocytosis

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