1 / 5

Identification and Recognition of Chemical Agents using Peptides and Metals

This study explores peptides and metals for detecting and discriminating various chemical agents like VX, sarin, and pesticides. Peptides with hydrophobic/hydrophilic properties and metal selectivity provide a method for differentiating these agents. The research focuses on using peptide/metal receptors to differentiate nerve agents from pesticides, showing promise in environmental assessment and security applications.

anne
Télécharger la présentation

Identification and Recognition of Chemical Agents using Peptides and Metals

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. O CH CH CH CH CH CH CH CH CH CH CH CH CH O 3 3 3 3 3 3 3 3 3 3 3 3 3 P N S CH 3 H C 3 CH 3 VX O H C H C H C H C 3 3 3 3 O P F sarin CO Et 2 NO 2 CO Et 2 parathion Target agent: VX O N O acetylcholine Other chemical agents: O O O N P P F CN soman tabun Pesticides: S S O O P P O O O S malathion

  2. O CH CH CH CH CH O 3 3 3 3 3 P N S CH 3 H C 3 CH 3 VX H C 3 Target agent: VX O N O acetylcholine Acetylcholinesterase

  3. CH CH CH CH CH CH CH CH 3 3 3 3 3 3 3 3 O H C H C H C 3 3 3 O P F sarin CO Et 2 NO 2 CO Et 2 parathion Organophosphorus Compounds Other chemical agents: O O O N P P F CN soman tabun Pesticides: S S O O P P O O O S malathion

  4. NH N N H 2 2 H NH NH NH 2 NH N 2 2 2 N H H Peptides that recognize VX Dr. Cyndi Wells, Dr. Ben Warner, Los Alamos Natl. Lab. NH2-Ser-GG-Arg-GG-His-GG-His-Phe NH2-Arg-GG-Ser-GG-His-GG-Ser-Phe NH2-Trp-GG-His-GG-His-GG-Trp-Phe NH2-Arg-GG-Tyr-GG-Arg-GG-Ser-Phe NH2-Tyr-GG-Trp-GG-Tyr-GG-Trp-Phe NH2-His-GG-His-GG-His-GG-Arg-Phe O O O O NH O N HO OH HO HO HO HO OH Ser Arg His Tyr Trp

  5. Peptide: hydrophobic/hydrophilic, shape, size Metal: functional group discrimination H C 3 methylphosphonic acid thiophosphates from nerve agents from pesticides H O H C 2 H C 3 3 m ethylphosphonic e thanol m ercaptoamine acid Selectivity and Recognition:Peptide/metal receptors O O S OH OH OH P P P HO OH HO OH OH phosphates from soil differentiate by metal differentiate by peptide Degradation Products: O O HS N O OH P + + P + HO OH S N VX

More Related