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Sequence from Exon 1 Deleted

Identification of five processed SHP2 pseudogenes in the human genome. SH2. SH2. PTP Domain. Exon 1. 3. 4. 5. 6. 7. 8. 9. 12. 13. 14. 15. 2. 10. 11. SHP2 Gene ( PTPN11 ). 1. 4. 5. 55. 56. 110. 111. 175. 176. 213. 214. 252. 253. 284. 285. 311. 312. 364. 365.

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Sequence from Exon 1 Deleted

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  1. Identification of five processed SHP2 pseudogenes in the human genome SH2 SH2 PTP Domain Exon 1 3 4 5 6 7 8 9 12 13 14 15 2 10 11 SHP2 Gene (PTPN11) 1 4 5 55 56 110 111 175 176 213 214 252 253 284 285 311 312 364 365 407 408 458 459 482 483 532 533 571 572 593 5’ UTR 3’ UTR Thr411 1 593 SHP2 cDNA 5’UTR 3’UTR ATG TAG 1179 AAAA -208 1 1 224 280 593 SHP2-P3 Pseudogene 94,3% Identity ATG TAG -208 312 bp insertion AAAA 171 283 593 SHP2-P4 Pseudogene 95,0% Identity ATG TAG 513 AAAA 1 54 111 175 593 SHP2-P5 Pseudogene Sequence from Exon 4 deleted 94,8% Identity ATG TAG -203 AAAA 5 17 593 SHP2-P6 Pseudogene Sequence from Exon 1 Deleted 92,6% Identity TAG 15 1 4 56 593 SHP2-P8 Pseudogene 93,9% Identity ATG TAG -201 318 bp insertion between Exon 2 and 3 > 1000 bp insertion http://ptp.cshl.edu or http://science.novonordisk.com/ptp Andersen et al (FASEB J) 2003

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