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Ca 2+ PowerPoint Presentation

Ca 2+

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Ca 2+

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  1. Acute Sulfonylurea therapy at disease onset can cause permanent remission of KATP-induced diabetesRemedi MS et al. Diabetes. 2011; 60:2515-2522

  2. Healthy Neonatal Diabetes High Glucose Ca2+ • Mutations: • KCNJ11 • - ABCC8 (SUR1) Kir6.2 SUR1 Depolarization Insulin Secretion ATP K+ High ATP/ADP ratio

  3. Healthy Neonatal Diabetes Sulfonylureas High Glucose Ca2+ • Mutations: • KCNJ11 • - ABCC8 (SUR1) Kir6.2 SUR1 Depolarization Different outcomes Insulin Secretion ATP K+ High ATP/ADP ratio

  4. Healthy Neonatal Diabetes Sulfonylureas High Glucose Ca2+ • Mutations: • KCNJ11 • - ABCC8 (SUR1) Kir6.2 SUR1 Depolarization Different outcomes Insulin Secretion ATP K+ High ATP/ADP ratio Mouse neonate • KATP dependent neonatal diabetes • Hyperglycemia • Loss of β-cells

  5. Healthy Neonatal Diabetes Sulfonylureas High Glucose Ca2+ • Mutations: • KCNJ11 • - ABCC8 (SUR1) Kir6.2 SUR1 Depolarization Different outcomes Insulin Secretion ATP K+ High ATP/ADP ratio Mouse neonate Sulfonylureas 6 days • KATP dependent neonatal diabetes • Hyperglycemia • Loss of β-cells Early onset of neonatal diabetes

  6. Healthy Neonatal Diabetes Sulfonylureas High Glucose Ca2+ • Mutations: • KCNJ11 • - ABCC8 (SUR1) Kir6.2 SUR1 Depolarization Different outcomes Sulfonylureas Insulin Secretion Not cured (70%) ATP K+ High ATP/ADP ratio Cured (30%) Fed Glucose Mouse neonate Sulfonylureas time 6 days • KATP dependent neonatal diabetes • Hyperglycemia • Loss of β-cells Early onset of neonatal diabetes Insulin Content Not Cured Cured

  7. Healthy Neonatal Diabetes Sulfonylureas High Glucose Ca2+ • Mutations: • KCNJ11 • - ABCC8 (SUR1) Kir6.2 SUR1 Depolarization Different outcomes Sulfonylureas Insulin Secretion Not cured (70%) ATP K+ High ATP/ADP ratio Cured (30%) Fed Glucose Mouse neonate Sulfonylureas time 6 days • KATP dependent neonatal diabetes • Hyperglycemia • Loss of β-cells Early onset of neonatal diabetes Insulin Content Not Cured Cured