Hemophilia definition : Causes the person to bleed more.

1. Hemophilia Hemophilia definition: Causes the person to bleed more.

2. Alternative names: MOST COMMON-Hemophilia A Classic hemophiliaFactor VIII deficiency Hemophilia B Christmas diseaseFactor IX deficiency

3. Who is most likely to get disorder: Hemophilia is an inherited blood disorder, but a person can get the disorder without inheriting it as well , also hemophilia is  usually passed to males from their mother. Which causes the probability to have hemophilia  in the sons of women who carry the hemophilia gene. Hemophilia can occur in any race/ethnic groups. So basically hemophilia is most likely to be a disorder which males carry and there is no specific race with this disorder.

4. Describe Symptoms: • These symptoms may be occur shortly after birth; Bleeding into the muscle, • resulting in a deep bruise after receiving a routine vitamin K shot • Prolonged bleeding after a male child is circumcised • In rare cases, prolonged bleeding after the umbilical cord is cut at birth • Bleeding into a joint or muscle that causes pain and swelling • Abnormal bleeding after an injury or surgery • Easy bruising • Frequent nosebleeds • Blood in the urine • The bleeding can occur in many organs for example the joints; the elbow joint and the knee joint, ect. Also bleeding in the brain may occur. When trying to look at a person with hemophilia and trying to recognize the disorder it can be hard because some of the symptoms you might see like frequent nosebleeds or easy bruising but some are harder to recognize like blood in urine(by another person) bleeding into a joint or muscle that causes pain and swelling. So you can recognize the disorder depending on the type of symptom the person has.

5. How common is the disorder: Hemophilia is on of the more rare genetic disorders; Hemophilia A occurs in 1 out of 10,000 men in the United States. About 20,000 people in the United States have hemophilia.

6. Is the disorder deadly? Will it shorten life span?: Hemophilia is a deadly disease that decreases the body’s ability to create blood clots. The life span of someone with hemophilia depends on whether they receive proper treatment. Without receiving treatment, many people with hemophilia die before they reach adulthood. However, with proper treatment, life span for people with hemophilia is about 10 years less than that of males without hemophilia, and children can expect a normal life span.

7. Can you be tested for the disorder? If so how and when? Blood tests can help determine whether you have hemophilia. Also Genetic tests are available if you want to know whether you are a carrier of hemophilia. (Only females can be carriers). Most of the time this disorder is diagnosed when the person is an infant.

8. Is there treatment? Does it cure or treat symptoms? There are treatment, the treatments depend on how severe the hemophilia is, there are two basic ways you can get the disorder treated. First (on demand) - which gives treatment to stop bleeding when it occurs, more common with people who have mild hemophilia. The second way is preventative treatment - medication to prevent bleeding when hurt and when there is joint and/or muscle damage. More common for people who have medium/severe hemophilia. You can also use the clotting factor replacement therapy to treat the disorder. People with hemophilia who get some sort of treatment can prevent some symptoms but there is no cure.

9. Are there any support groups?    Yes, there are many support groups. For example: Cincinnati children hospital, The Hemophilia foundation of Michigan.

10. Some Facts: Bleeding in the head and sometimes in the brain leading to brain damage Nearly 90% of Americans with severe hemophilia became infected with HIV  in the 1980s when the nation’s blood supply was contaminated  by blood pooled from people infected by HIV/AIDS. Death can occur if the bleeding cannot be stopped or if it occurs in a vital organ such as the brain

11. Inheritance patterns of Hemophilia: A male who has the strange gene on his X chromosome will have hemophilia. A female must have the strange gene on both of her X chromosomes to have hemophilia; this is very rare. A female is a "carrier" of hemophilia if she has the strange gene on one of her X chromosomes. Even though she doesn't have the disorder, she can pass the gene on to her children. Also X-linked recessive are usually inherited by males from their mother for hemophilia.

12. Location, what chromosome/gene is it located on?Hemophilia disorder is located on the X Chromosome.

13. Works Cited "Haemophilia." Wikipedia, the Free Encyclopedia. Web. 25 Jan. 2011. <http://en.wikipedia.org/wiki/Haemophilia>. "Hemophilia - Genetics Home Reference." Genetics Home Reference - Your Guide to Understanding Genetic Conditions. Web. 25 Jan. 2011. <http://ghr.nlm.nih.gov/condition/hemophilia>. "Hemophilia." KidsHealth - the Web's Most Visited Site about Children's Health. Web. 25 Jan. 2011. <http://kidshealth.org/teen/diseases_conditions/blood/hemophilia.html>.

14. ASAD QUDDUS PERIOD 4 Biology