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0 6 12 24 0 6 12 24 0 6 12 24 hours

A. 0 1 3 6 0 1 3 6 0 1 3 6 hours. c-Jun. 0 6 12 24 hours. p-JNK. p-JNK. 0 6 12 24 0 6 12 24 0 6 12 24. JNK. JNK. 0 6 12 24 0 6 12 24 0 6 12 24 hours. p - Erk1/2. β - actin. control. Erk1/2.

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0 6 12 24 0 6 12 24 0 6 12 24 hours

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  1. A. 0 1 3 6 0 1 3 6 0 1 3 6 hours c-Jun 0 6 12 24 hours p-JNK p-JNK 0 6 12 24 0 6 12 24 0 6 12 24 JNK JNK 0 6 12 24 0 6 12 24 0 6 12 24 hours p- Erk1/2 β-actin control Erk1/2 c-Jun p-p38 JSI-124 0 0.2 0.5 1 5 JSI-124 (uM) 0 0.2 0.5 1 5 0 0.2 0.5 1 5 β-actin p38 p- c-Jun (ser63 ) primary CLL cells c-Jun 7-AAD BJAB I-83 NALM6 1.4% β-actin Annexin -V BJAB I-83 NALM-6 B.i. ii. C. D. β-actin p-c-Jun (Ser63) β-actin BJAB I-8 NALM6 E. 0.43% β-actin Percentage of accumulation of the sub-G1 peak 1.12% BJAB I-83 NALM6 0.31%

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