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Investigating the Effects of PEM on Puma Expression and Apoptotic Markers in A549 and H1792 Cells

This study examines the impact of PEM at varying concentrations (0.2 to 10 μmol/L) on Puma expression and apoptosis-related markers in A549 and H1792 lung cancer cell lines. Time-course analyses (0 to 48 hours) were conducted to evaluate the levels of Puma, Noxa, Mcl-1, Caspase-3, Caspase-9, and PARP, alongside β-actin as a loading control. Figures S1 and S2 illustrate the siRNA knockdown effects on Puma and associated apoptotic pathways, highlighting potential therapeutic implications in cancer treatment.

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Investigating the Effects of PEM on Puma Expression and Apoptotic Markers in A549 and H1792 Cells

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  1. A549 PEM (mol/L) 0 2.5 5.0 10 Puma -actin H1792 0 2.5 5.0 10 a b Time (hour) 0 12 24 36 48 — — ＋ — ＋ — ＋ — ＋ PEM (2.5mol/L) Puma A549 -actin Puma H1792 -actin Figure S1

  2. A549 a b siRNA Ctrli Pumai Noxai Pi+Ni - + - + - + - + PEM Puma Noxa Mcl-1 Caspase 9 Caspase 3 PARP β-actin Figure S2

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