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Time (hour) 0 12 24 36 48

A549. PEM (  mol/L). 0 2.5 5.0 10. Puma.  -actin. H1792. 0 2.5 5.0 10. a. b. Time (hour) 0 12 24 36 48. — — ＋ — ＋ — ＋ — ＋. PEM (2.5  mol/L). Puma. A549.  -actin. Puma. H1792.  -actin.

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Time (hour) 0 12 24 36 48

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  1. A549 PEM (mol/L) 0 2.5 5.0 10 Puma -actin H1792 0 2.5 5.0 10 a b Time (hour) 0 12 24 36 48 — — ＋ — ＋ — ＋ — ＋ PEM (2.5mol/L) Puma A549 -actin Puma H1792 -actin Figure S1

  2. A549 a b siRNA Ctrli Pumai Noxai Pi+Ni - + - + - + - + PEM Puma Noxa Mcl-1 Caspase 9 Caspase 3 PARP β-actin Figure S2

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