THE IMMUNE SYSTEM

1. THE IMMUNE SYSTEM The Invaders The Defender

2. COMPONENTS OF THE IMMUNE SYSTEM Cellular components of the immune system Lymphocytes Granulocytes Others Phagocytes B-cell Mononuclear phagocyte Basophil Platelets T-cell Neurtrophil Mast cell Large granular lymphocyte Eosinophil Antibodies Cytokines Complement Inflammatory mediators Soluble mediators of the immune system

3. ORIGINATION OF CELLULAR COMPONENTS Lymphoid stem cell T-cell B-cell Plasma cell Natural killer cell Pluripotent Stem cell Neutrophil Monocyte Eosinophil Basophil Mast cell Platelets Myeloid Stem cell Macrophage

4. THE EVOLUTION OF IMMUNITY Immunity Non-specific Immediate onset Specific Delay onset Innate immunity Acquiredimmunity Humoral Immune Response Cellular Immune Response Antibodies production T-cell activation

5. INNATE IMMUNITY Pathogenic invasion Bacteria Viruses 1st Line Defense Skin Ciliatedcells Lysozyme Coughing Vomitting 2nd Line Defense Blood clot Mast cell Cytokines Leukocytes

6. THE INFLAMMATORY RESPONSE Tissue injury caused by pathogenic invasion Increased capillary permeability Capillary widening Leukocyte attraction Systemic response Increased blood flow Release of fluid Leukocytic migration Leukocytic proliferation Heat, Redness, Tenderness, Swelling, Pain

7. THE COMPLEMENT CASCADE Alternative Classical Antibody binding Mannose binding The Complement System Opsonization Inflammation Cytolysis

8. ACQUIRED IMMUNITY Humoral Immunity Cytokines B-Cell Activation Activated TH cell Antibodies Production Cytokines Cytotoxic T-Cell Activation Cell lysis Cell-mediated Immunity

9. ATTRIBUTES OF ACQUIRED IMMUNITY Immunological Specificity Immunological Tolerance Receptor APC Immunological memory Activated T-cell B-cell Plasma cell Memory B-cell Mature T-cell Memory T-cell

10. THE MHC PROTEINS: CLASS I

11. THE MHC PROTEIN: CLASS II

12. RECOGNITION OF CLASS I MHC PROTEIN

13. RECOGNITION OF CLASS II MHC PROTEIN