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Immunology Overview

0. Immunology Overview. Non-specific, rapid Physical, Chemical Barriers Complex Biochemical Mechanisms Fever Inflammation Complement Toll and Nod. Antigen specific and initially slow Memory Lymphocytes Humoral and Cellular Exquisitely Specific Recognition molecules. 0.

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Immunology Overview

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  1. 0 Immunology Overview

  2. Non-specific, rapid Physical, Chemical Barriers Complex Biochemical Mechanisms Fever Inflammation Complement Toll and Nod Antigen specific and initially slow Memory Lymphocytes Humoral and Cellular Exquisitely Specific Recognition molecules 0 Innate vs Acquired Immunity

  3. 0 Eukaryote Innate Immunity

  4. 0 Cells of the Immune System

  5. 0 The Immune System

  6. 0 The Clonal Selection Theory

  7. 0 Primary vs Secondary Response

  8. 0 Antigenicity • Antigen - any molecule that binds to and activates the specific receptors of lymphocytes • Immunogenicity • Specificity • Epitopes • Some molecules (haptens) have specificity but no immunogenicity -- these need a carrier • Digoxigenin • peptides

  9. 0 DIG - KLH

  10. 0 Requirements for Immunogenicity • Foreignness • High Molecular Weight • Chemical Complexity • Degradability • Host Factors • Genetics • Route of encounter / Adjuvants

  11. 0 Protein Structure

  12. 0 Myoglobin Epitopes

  13. 0 Lysozyme Epitopes

  14. 0 Compare Epitope Structures

  15. 0 Antibody Structure

  16. 0 The 5 Antibody Classes

  17. 0 Mammalian Antibody Isotypes

  18. 0 The Immunoglobulin Superfamily

  19. 0 The Central Dogma

  20. 0 and GOD said, “Let there be light chains!”

  21. 0 Light chain exon rearrangement

  22. 0 “and let there be heavy chains!”

  23. 0 The Clonal Selection Theory

  24. 0 Monoclonal Antibodies

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