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Telomerase Expression and Telomeric Stabilisation

Telomerase Expression and Telomeric Stabilisation. Telomeres. Protective caps . Prevent chromosomal fusion. Short 5-8 bp tandem repeated G rich segments (TTAGGG). L ength decreases with progressive rounds of cell replication, concluding in cell senescence. Telomerase.

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Telomerase Expression and Telomeric Stabilisation

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  1. Telomerase Expression and Telomeric Stabilisation

  2. Telomeres • Protective caps . • Prevent chromosomal fusion. • Short 5-8 bp tandem repeated G rich segments (TTAGGG). • Length decreases with progressive rounds of cell replication, concluding in cell senescence.

  3. Telomerase • Maintains telomere length. • Dictates synthesis of telomeric repeats onto DNA substrates. • Telomerase expression increases with grade of CIN. • Active form of telomerase is hTERT. • Full length RNA is called hTR. • Quantitative differences in expresion of hTR telomerase in normal, CIN and invasive phenotypes.

  4. Quantitative Analysis of telomeres

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