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US EPA ORD PATHFINDER INNOVATION PROJECT

International Steering Committee on Multimedia Environmental Modeling (ISCMEM) Annual Meeting NRC HQ, Rockville MD November 28, 2011. US EPA ORD PATHFINDER INNOVATION PROJECT. Global to Genome (G2G). Outline. Pathfinder project Global to Genome Team G2G Problem and Promise

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US EPA ORD PATHFINDER INNOVATION PROJECT

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  1. International Steering Committee on Multimedia Environmental Modeling (ISCMEM) Annual Meeting NRC HQ, Rockville MD November 28, 2011 US EPA ORDPATHFINDER INNOVATION PROJECT Global to Genome (G2G)

  2. Outline • Pathfinder project • Global to Genome • Team G2G • Problem and Promise • Process and Products • Partnerships • Progress • Open Discussion

  3. ORD Initiative:Pathfinder Innovation Project (PIP) • Paul Anastas’ set-aside in Fall 2010 to stimulate new ORD research • Emphasis on innovation and sustainability • 1-year seed project • Competition announced in October 2010 with rapid time frame • Proposals submitted directly to the HQ Innovation Team, then reviewed by one of three external panels of highly-regarded scientific, innovation, and sustainability experts • 117 proposals and > 200 scientists participated • 12 Awards in January 31, 2011 • Based on recommendations from the three external panels • G2G considered a “Game Changer”

  4. Global to Genome (G2G) Goal: Specification of a Computational Platform for Agency-wide, Seamless Data Flow and Computational Modeling in Support of Health, Ecological, and Climate Risk Characterizations

  5. G2G: Semantics! • Innovation is intentionally a high risk endeavor • Specifications ONLY – we are NOT building the system • Implementation in out years • Support to RAP projects and models • Technology versus terminology! • Scope: Modular – not a behemoth system • Expected to evolve with time • Cover across all of EPA • Provide public access

  6. Team G2G Members across several ORD centers and labs • NCEA: Lyle Burgoon, Annie Jarabek, and David Miller • NHEERL: Rory Conolly, Stephen Edwards, and William LeFew • NERL: Michael Breen, Rocky Goldsmith, and Cecilia Tan • OSIM: David Lyons

  7. Critical Peer-review Partners • Across Agency • OAR/OAQPS; OSWER, OPPT, OW, OEI • NHSRC • Regional offices • External stakeholders • Professional societies (SOT, SETAC, ISES, SRA, iEMSs…) • Academia • Private sector

  8. G2G: Central Role in AdvancingNew Research Area Programs Source: P. Preuss, “ORD Innovation” to Agency Scientific Advisory Board (SAB) and Board of Scientific Counselors (BOSC), June 29, 2011.

  9. CSS Dashboards G2G: Central Role in AdvancingNew Research Area Programs ACE Modeling/ Decision Support SSWR G2G SHC Decision Analysis & Support

  10. G2G: Problem and Promise

  11. GIS Physicochemical Data Toxicicity / Health Effects Data Example: Data Streams Required in Risk Assessment Transport & Transformation Model(s) Dosimetry Model(s) Response Model(s) Dose-response Analyses Cost:Benefit Evaluations Exposure Model(s) Exposure Assessment Management Options Risk Assessment Adverse Outcome Analyses Ecotoxicological Effects Data

  12. G2G: Process Several simultaneous, iterative steps: • Scope:Stakeholder solicitation of needs, applications, and available model inventory • Refine: Specifications for integration with emphasis on • Being user friendly • Ease of portability • Public access • Review:Critical peer-review partners to continue to input and refine specifications • Review of recommendations • SOT CCT Workshop in May 2012

  13. Example Interview Agenda • 8:00 – 9:00 pm G2G Overview briefing • Overview of the day's schedule • Background on the G2G project • Discussion on our interview process • How to stay abreast of our project • 9:00 – 3:00 pm Individual interviews • (45 min each) • 3:00 – 3:30 pm G2G Team meeting / summary prep • 3:30 – 4:00 pm Exit briefing

  14. G2G: Progress • Interviews began in FY12 • NCEA RTP completed • NERL and NCCT underway • NHEERL is this week (Nov 30 and Dec 1) • Remaining interviews will take through April 2012 • All ORD labs and centers • All program offices • All regions • DRAFT recommendations updated each time as we analyze feedback

  15. SOT CCT WorkshopContemporary Concepts in Toxicology • International, co-sponsored by SETAC, ISES, SRA, iEMSs, FDA NCTR, DOE PNNL, DOD ACE, USGS, NRC…. • May 8 -11, 2012 at EPA RTP facility • DRAFT G2G recommendations to be externally vetted • Focus on interoperability and multi-scale data integration • Poster session opportunity to highlight research and demonstrate data integration projects

  16. G2G: Products • Requirements document: Systems design description for subsequent implementation • Demonstration: Utility and impact on assessment approaches and operational efficiency • Case studies • Two hazardous air pollutants (vinyl chloride and chlorine) to link to virtual tissues • Chlorpyrifos • Discuss needs for broader implementation to other agents (e.g., PM) and media (e.g., water, soil) to support sustainability emphasis across ORD research programs • Forum article in Toxicological Sciences

  17. Additional Considerations: Culture Change • G2G = Great idea! • Technically challenging, but the social engineering required may be even more formidable: • Data sharing • Collaborative development versus end-product interfacing • Iterative, “modeling mentality” • Implementation in research as well as regulatory context

  18. Global Discussion • Project Page : https://kestrel.rtpnc.epa.gov/scidata/?page_id=507 • Updates page: https://kestrel.rtpnc.epa.gov/scidata/?cat=16

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