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Insights into Selectivity-Determining Regions of PTP Active Sites and Their Role in Substrate Recognition

The study explores non-conserved amino acids near the PTP active site that play crucial roles in recognizing peptide substrates and non-peptide inhibitors. Key regions such as the SHP specificity region, WPD-loop, and the second pTyr binding site are analyzed. The conservation degree of these amino acids is indicated by a color scale, providing insight into evolutionary variation among 37 aligned human PTP catalytic domains. Understanding these dynamics can enhance our knowledge of PTP specificity and its impacts on cellular signaling.

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Insights into Selectivity-Determining Regions of PTP Active Sites and Their Role in Substrate Recognition

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  1. Selectivity-determining regions Nonconserved amino acids in the proximity of the PTP active site (yellow) are involved in recognition of peptide substrates and non-peptide PTP inhibitors SHP specificity region S118 WPD-loop specificity F182 D48 R47 R24 G259 KNRY-loop specificity Second pTyr binding site The degree of conservation (blue – most conserved, red least conserved) reflects the Ca-regiovariation score values of 37 aligned human PTP catalytic domains. http://ptp.cshl.edu & http://science.novonordisk.com/ptp Andersen et al Mol. Cell. Biol. 2001

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