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fBIRN Human Phantom Reproducibility Analysis

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fBIRN Human Phantom Reproducibility Analysis. Prepared by Kelly H. Zou, PhD Analyzed by Meng Wang, MSE Surgical Planning Laboratory Brigham and Women’s Hospital Harvard Medical School 1-7-03. Voxel-Based Reproducibility Analysis. • Multi-Site BIRN Study: 11 Sites

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fBIRN Human Phantom Reproducibility Analysis

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  1. fBIRN Human Phantom Reproducibility Analysis Prepared by Kelly H. Zou, PhDAnalyzed by Meng Wang, MSESurgical Planning Laboratory Brigham and Women’s Hospital Harvard Medical School 1-7-03

  2. Voxel-Based Reproducibility Analysis •Multi-Site BIRN Study: 11 Sites (MN, UCI, UNC, UCLA…, BWH, MGH) •5 Healthy males as “Human Phantoms” •2 Days (Visits) per site per subject •4 Sensory Motor (SM), 2 cognitive (Cog), and 2 breath-hold (BH) runs per day

  3. Participating Institutions

  4. Materials and Methods •Focus on Reproducibility of the SM Task Only: •Subjects perform bilateral finger tapping on button boxes (1 dummy button box and 1 actual) in time with 3Hz audio cue and flashing checkerboard square •Subjects press buttons 1 through 4 in consecutive order and then back again using both hands at simultaneously and in sync •Time frames=85; Scan time=4:06; Days 1 and 2

  5. Scan Protocol

  6. Partial Data Examined and Compared •Task: Sensory Motor •Site:5 Sites under 1.5T and 3 Sites under 3T •Subject:#101; 103; 104; 105; 106 •Run: 4 and registered—Later combined by EM • Day:#101; 103; 106 tested on 4 days at Stanford and other subjects tested on 2 Days/Site •Threshold:  = – log10(p-value)sign(F-statistic) = 5; 7; and 9

  7. Results: See the List of Figures •Activation Percentage; Sensitivity; and Specificity vs.the estimated “gold standard” by STAPLE (an EM-Algorithm) in Slicer over the 4 runs/day •Figures in pdf format are in the folders: Folder 1 (“3Sites-3T-5Humans”): 3T only 5 Humans; 3 Sites: MGH, STAN, MIN Folder 2 (“5Sites-1.5T-5Humans”): 1.5T only 5 Humans; 5 Sites: IOWA, DUNC, UCI, UCSD, NM Folder 3 (“Stanford-4Days-3T-3Humans”): 3T only 3 Humans; 1 Site: STAN

  8. Summary •Field Strength: 3.0T was better than 1.5T yielding more activation and less variability in sensitivity and specificity • Runs: There was a "zig-zag" effect over the runs (registered) after the rest and task periods • Days:Less activation was observed and more robust and systematic activation under different thresholds for Day 2 than Day 1

  9. Summary • Extra Days (Days 1-4): For the three subjects performing for 4 days at Stanford, less activation was observed for the latter two days with higher specificity and less variability. Variability across runs was quite high • Site vs. Subject: The variability across site appeared to be greater than variability across subjects

  10. Future Research • p-values based on ANOVA for statistical significance • Abstract for HBM deadline (1/15) and authorship • Ghosting in the data and other issues • Registration to overlay echo-planar data • Reliability maps and ROI analysis

  11. Acknowledgment • Grant ID: P41IRR131218 • List of Authors and Investigators: List Here…

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