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Training Core Update Sonia Pujol, PhD Randy Gollub, MD, PhD Harvard Medical School

Training Core Update Sonia Pujol, PhD Randy Gollub, MD, PhD Harvard Medical School. NA-MIC outreach activities at international conferences. Radiologists. NA-MIC Workshop for Radiology residents, Brigham & Women’s Hospital, Boston, MA. Radiologists.

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Training Core Update Sonia Pujol, PhD Randy Gollub, MD, PhD Harvard Medical School

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  1. Training Core UpdateSonia Pujol, PhDRandy Gollub, MD, PhDHarvard Medical School

  2. NA-MIC outreach activities at international conferences

  3. Radiologists • NA-MIC Workshop for Radiology residents, Brigham & Women’s Hospital, Boston, MA

  4. Radiologists • NA-MIC Workshop for Radiology residents, Brigham & Women’s Hospital, Boston, MA • Hands-on training on 3D visualization of the Anatomy

  5. Radiologists • Task-oriented course on the liver segments RSNA 2009, Chicago, IL

  6. Radiologists • Task-oriented course on the liver segments RSNA 2009, Chicago, IL • Course score on the RSNA evaluation form: 4.13/5.00

  7. Neurosurgeons • Hands-on training workshop in Image-Guided Therapy for neurosurgeons • IBMISPS 2009 conference, Boston, MA A. Golby, N. Hata, H. Liu

  8. Autism Researchers • NA-MIC presentation at the annual meeting of the International Society for Autism Research IMFAR 2009, Chicago, IL “Use of the Slicer3 toolkit to produce regional cortical thickness measurements of pediatric MRI data “ Heather Cody et al., IMFAR 2009 H.Cody

  9. Orthopedic Surgeons • 3D Visualization Workshop for Image-guided Therapy applications in Orthopedic Surgery • Annual Meeting of the International Society for Computer Assisted Orthopaedic Surgery (CAOS 2009), Boston MA

  10. Neuroscientists • ‘Mapping the Brain with Diffusion Tensor Imaging’ • One-day NA-MIC Workshop • on DTI Analysis • Annual Meeting of the Society for Neuroscience, • SFN 2009, Chicago IL

  11. Integration with CTSAs • New partnership with the NIH NCRR funded Clinical Translational Science Awards (CTSAs) national Imaging Working Group

  12. Integration with CTSAs • New partnership with the NIH NCRR funded Clinical Translational Science Awards (CTSAs) national Imaging Working Group • Greatly expands the end-user community exposure to the NA-MIC kit

  13. Integration with CTSAs • New partnership with the NIH NCRR funded Clinical Translational Science Awards (CTSAs) national Imaging Working Group • Greatly expands the end-user community exposure to the NA-MIC kit • Provides critical clinically relevant driving forces for new developments

  14. Joint Workshop on Imaging Biomarkers • Workshop on Quantitative Medical Imaging for Clinical Research and Practice -RSNA 2009, Chicago, IL

  15. Joint Workshop on Imaging Biomarkers • Workshop on Quantitative Medical Imaging for Clinical Research and Practice -RSNA 2009, Chicago, IL • Course score on the RSNA evaluation form: 4.26/5.00

  16. Joint Workshop on Imaging Biomarkers • Workshop on Quantitative Medical Imaging for Clinical Research and Practice -RSNA 2009, Chicago, IL • Course score on the RSNA evaluation form: 4.26/5.00 • More than 100 attendees

  17. New PET/CT Fusion Module PET/Fusion Module Programming &Tutorial: Wendy Plesniak, Ph.D. Special Thanks to Kathryn Hayes

  18. Harvard Catalyst (CTSC) • Jointly sponsored Slicer workshops delivered on a regular basis.

  19. Harvard Catalyst (CTSC) • Jointly sponsored Slicer workshops delivered on a regular basis. • 1-hour hands-on training sessions on medical image analysis at Harvard Medical School

  20. Tutorial Contests • Winter Project Week 2009, Salt Lake City • Summer Project Week 2009, Boston • Winter Project Week 2010, Salt Lake City 17 new additions of tutorials and training datasets to the NA-MIC Compendium

  21. NA-MIC Compendium NA-MIC Training Compendium & Workshops

  22. NA-MIC Compendium 1595 tutorial slides on 27 different topics in medical image analysis

  23. NA-MIC outreach activities 2005-2009: More than 900 scientists and clinicians trained by NA-MIC at national and international venues

  24. DTI Tractography Validation Update Sonia Pujol, Ph.D.Harvard Medical School

  25. DTI Validation Challenge • Comparison of DTI tractography algorithms in the absence of ground truth

  26. DTI Validation Challenge • Comparison of DTI tractography algorithms in the absence of ground truth • Evaluation of different DTI tractography approaches in the absence of common platform

  27. Tractography errors Optic radiation Optic chiasm Courtesy of Dr. JJ Lemaire

  28. Step1: Implementation of the Validation Framework Fiber Tracking SCI, Utah Streamline BWH, Harvard Volumetric Connectivity SCI, Utah GTRACT Iowa University 3D Slicer

  29. Step 2: Implementation of the Validation Pipeline Warfield SK, Zou KH, Wells WM. Simultaneous Truth and Performance Level Estimation (STAPLE): An algorithm for the Validation of Image Segmentation. IEEE Trans Med Imaging. 23(7):903-21.

  30. Step 3: Evaluation of the Validation Method • Evaluation of the accuracy and precision of the validation framework in synthetic data experiments. STAPLE estimate tractography performances are accurate

  31. Experiment 1: STAPLE Analysis applied to DTI • Preliminary results on three different fascicles showed differences in sensitivity among algorithms. Internal Capsule A1: Fiber Tracking A2: 3DSlicer A3: GTract A4: Volumetric Connectivity

  32. Abstract Presented at ISMRM 2009 Preliminary results on the use of STAPLE for evaluating DT-MRI tractography in the absence of ground truth S.Pujol, C-F Westin, R.Whitaker, G.Gerig, T.Fletcher, V.Magnotta, S.Bouix, R.Kikinis, W.Wells III, R.Gollub. ISMRM 2009, Apr.18-24 2009, Honolulu, Hi

  33. STAPLE Analysis applied to DTI • Preliminary results showed differences in sensitivity among algorithms

  34. STAPLE Analysis applied to DTI • Preliminary results showed differences in sensitivity among algorithms • Question: What is the statistical significance of the differences observed ?

  35. Experiment 2: Statistical Analysis 25 DWI datasets

  36. Experiment 2: Statistical Analysis • The statistical analysis showed significant differences in sensitivity among 3D segmentations of the Arcuate Fasciculus by different algorithms Arcuate Fasciculus A1: Fast Marching A2: GTract A3: Streamline A4: Stochastic

  37. Abstract presented at MICCAI 2009 DMFC Workshop Towards Validation of DTI Tractography: Statistical Analysis of the Differences Observed Among Tractography Algorithms S.Pujol, V.Magnotta, J.DeSiebenthal, M.Kubicki, K.Hayes, C-F.Westin, JJ.Lemaire, R.Kikinis, R.L. Gollub, W.Wells III . MICCAI 2009, Sept. 20-24, London, UK

  38. DTI Validation Milestones • Implementation of the validation framework • Evaluation of the validation framework • Preliminary DTI Tractography validation experiments • Statistical Analysis of the differences observed among algorithms

  39. DTI Validation Update

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