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Neisseria meningitidis

Explore the various aspects of bacterial meningitis caused by Neisseria meningitidis, including its morphology, virulence factors, epidemiology, transmission, clinical features, laboratory diagnosis, and immunization strategies. Learn about the different procedures and tests involved in diagnosing and treating this infectious disease.

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Neisseria meningitidis

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Presentation Transcript

  1. Neisseria meningitidis

  2. Morphology

  3. Virulence factors

  4. Epidemiology

  5. Diseases caused

  6. Meningitis

  7. Meningitis Infectious Non Infectious Viral Intracranial Tumors Bacterial Medications Fungal Systemic Illness Rickettsiae Procedure Related Spirochetes Parasites

  8. Meningitis Infectious Non Infectious Viral Intracranial Tumors Bacterial Medications Fungal Systemic Illness Rickettsiae Procedure Related Spirochetes Parasites

  9. Bacterial Meningitis

  10. Transmission

  11. Pathogenesis

  12. Nasopharyngeal Colonization Local Invasion Bacteremia Meningeal Invasion BacterialReplication Release of bacterial components

  13. Immune Response

  14. Clinical features

  15. -High temperature, fever, possibly with cold hands andfeet -Severeheadache. -Arash may develop. -Vomiting or refusingfeeds -Blank, staringexpression -Difficultto wake or lethargic -Stiff neck -Arched back -Baby may be floppy, may dislike being handled, befretful

  16. Signs

  17. RASH

  18. Laboratory diagnosis

  19. CSF Macroscopy Centrifuge Specimen and take deposits for bacteriological analysis Culture Examination Rapid Diagnostic Test Inoculate Direct examination CA MA BA Gram Stain Incubate 37oC, 24 hours. (BA & CA5 – 10 % CO2) Initial Report Examine colonies, Gram stain, biochemical, Serology. AST and Final report

  20. Growth characteristics

  21. Biochemical reactions

  22. Serology

  23. Immunization

  24. Meningococcemia

  25. Fulminant meningococcemia

  26. Thankyou

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