Pathways of Protein Degradation and Cell Signaling Mechanisms in Epithelial Cells
This lecture explores the intricate pathways of receptor protein degradation within lysosomes and various fates of intracellular signaling mechanisms. It covers how cholesterol is released from lysosomes, storage of glucose transporters in recycling endosomes, and the major protein sorting pathways in the trans-Golgi network. Furthermore, it delves into autocrine signaling processes that coordinate cellular differentiation and the dependence of animal cells on extracellular signals for survival, division, and function. Additionally, we discuss the roles of G-proteins, gene transcription activation, and the dynamic nature of microtubules and actin filaments in cellular processes.
Pathways of Protein Degradation and Cell Signaling Mechanisms in Epithelial Cells
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Presentation Transcript
cholesterol is released in lysosome
3 best understood protein sorting pathways in the trans Golgi network
Autocrine signaling allow a group of cells but not a single cell to respond to a differentiation signal coordinates decisions by a group of identical cells
An animal cell depends on extracellular signals to survive or divide
An animal cell depends on extracellular signals to differentiate. Without extracellular signals the cell will die
Extracellular signaling molecules can bind to intracellular receptors
Signaling molecules that bind to nuclear receptors are small and hydrophobic
G-protein accepts GTP and disassemble into two active subunits
Polymerization of tubulin is nucleated by the γ-tubulin ring
Two membrane system that relays signal to contract muscle cells
Cell growth like cell division is also stimulated by extracellular signals
Summary of junctional and non-junctional adhesive mechanisms
