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Additional File 7 K-means cluster graphs (15 clusters)

This analysis focuses on the gene expression dynamics across various phases of the cell cycle, including Middle G1, Early G1, Late G1, Early S, Late S, G1/S, and G2/M. Utilizing K-means clustering with 15 distinct clusters, we identify the increased expression of key genes such as BAX, TRAIL receptor 2, CD9, and EGFR. Additionally, we examine genes involved in ribosomal function and transcriptional regulation, revealing important insights into cellular processes and signaling mechanisms at different cell cycle stages.

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Additional File 7 K-means cluster graphs (15 clusters)

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  1. Additional File 7 K-means cluster graphs (15 clusters)

  2. Middle G1 Early G1 Late G1 Early S Late S G1/S G2 M

  3. Middle G1 Early G1 Late G1 Early S Late S G1/S G2 M

  4. Middle G1 Early G1 Late G1 Early S Late S G1/S G2 M

  5. Increased expression of genes including: BAX, BAX inhibitor 1, TRAIL receptor 2, CD9, EGFR, syndecan 4, signaling mediators, & genes involved in transcriptional regulation Middle G1 Early G1 Late G1 Early S Late S G1/S G2 M

  6. Middle G1 Early G1 Late G1 Early S Late S G1/S G2 M

  7. Middle G1 Early G1 Late G1 Early S Late S G1/S G2 M

  8. Middle G1 Early G1 Late G1 Early S Late S G1/S G2 M

  9. This set mostly includes ribosomal subunit genes as well as genes encoding beta-actin, beta-5-tubulin, and myosin light polypeptide Middle G1 Early G1 Late G1 Early S Late S G1/S G2 M

  10. Middle G1 Early G1 Late G1 Early S Late S G1/S G2 M

  11. Middle G1 Early G1 Late G1 Early S Late S G1/S G2 M Increased expression of genes including those encoding cathepsins L, L2, and Z, PPGB, EGFR, lamin B, poliovirus, leptin, MHC molecules, and solute/ion carrier transporters

  12. Middle G1 Early G1 Late G1 Early S Late S G1/S G2 M

  13. Middle G1 Early G1 Late G1 Early S Late S G1/S G2 M

  14. Middle G1 Early G1 Late G1 Early S Late S G1/S G2 M

  15. Middle G1 Early G1 Late G1 Early S G1/S Late S G2 M

  16. Middle G1 Early G1 Late G1 Early S Late S G1/S G2 M

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