Structural Insights into RyR: Charge Distribution and Molecular Crowding Dynamics

Jan 02, 2026

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This study by Samsó et al. (2005) explores the RyR (Ryanodine Receptor) structure, highlighting its unique properties characterized by four negative charges. The receptor is modeled as a cylinder with a length of 10 Å and a diameter of 8 Å, encompassing a total charge of 13 M. Notably, eight oxygen atoms contribute a significant negative charge of -1/2, occupying 18% of the available volume within the structure. This spatial arrangement indicates a highly crowded environment that may impact RyR function and interactions.

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Structural Insights into RyR: Charge Distribution and Molecular Crowding Dynamics

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Samsó et al., 2005 RyR • 4 negative charges • 10 Å-long, 8 Å-diameter cylinder • 13 M of charge! • 8 oxygens with charge -1/2 take up 18% of available volume • very crowded!