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IVD Antibody Development Services for TNF Marker

With abundant experience in IVD (in vitro diagnostics) antibodies development, Creative Biolabs is able to provide a full range of TNF marker antibodies development services for liver failure and sepsis screening and therapeutic monitoring. Our professional team is optimized to help you with high-quality and cost-effective service to make your project a success.

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IVD Antibody Development Services for TNF Marker

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  1. IVD Antibody Development Services for TNF Marker With abundant experience in IVD (in vitro diagnostics) antibodies development, Creative Biolabs is able to provide a full range of TNF marker antibodies development services for liver failure and sepsis screening and therapeutic monitoring. Our professional team is optimized to help you with high-quality and cost-effective service to make your project a success. Tumor Necrosis Factor (TNF) TNF, also known as troponin, is an inflammatory mediator. It is mainly produced by macrophages and can be induced by a variety of stimuli, such as IPS and immune complex viruses. The TNF produced by macrophages is named as TNF-α, the lymphotoxin produced by T lymphocytes is named TNF-β. Although TNF-α shares only about 30% homology with TNF-β, they share common receptors. The biological activity of TNFα accounts for 70% to 95% of the total activity of TNF. Therefore, TNF is often referred to as TNF-α. TNF has a dual effect, with antibacterial, antiviral, and immunoregulatory functions at the right dose, and adversely affects the body when abnormally increased or decreased. Fig.1 Crystal structure of TNF-α. TNF Marker of Liver Failure The cytokine TNF-α is an important cytokine, exerting biological effects in different tissues and species at multiple levels. It is a proinflammatory cytokine that mediates hepatic inflammation, oxidative stress, and apoptosis or necrosis

  2. of liver cells. TNF-α is a pleiotropic monocyte-derived cytokine that has been associated with cancer progression, severe inflammatory diseases, and liver injury. In order to fulfill inflammatory reactions in the tissue, TNF-α binds to two distinct receptors: TNFR1 and TNFR2. While TNFR1 is expressed in almost all tissue, TNFR2 is expressed only on inflammatory cells. Once TNF-α ligates TNFR1 the TNF receptor-associated protein with death domain (TRADD) is recruited to the death domain of TNFR1. Serum levels of TNF-α are significantly increased in fatty liver disease and are well correlated with the severity of liver disease. Plasma TNF-α levels also were significantly higher in patients with chronic hepatitis C, with liver cirrhosis, and hepatocellular carcinoma when compared to those with acute or mild chronic hepatitis C. Additionally, a positive correlation of soluble TNFR1 and soluble TNFR2 and disease progression were described in patients with chronic hepatitis C. Fig.2 The trimeric TNF-α engagement of TNFR1 leads to cellular apoptosis or cell survival via the distinct complex signaling pathways. (Yun, 2015) TNF Marker of Sepsis During tissue injury, binding of PAMP to PRR results in the release of NF-κB from its complex that is inactive in I-B. NF-κB is an important intracellular protein that can translocate to the nucleus and causes the transcription of pro-

  3. inflammatory cytokine TNF. The pro-inflammatory cytokine TNF further activates neutrophils, causing the expression of cell-adherent cofactor β- integrin (CD-11) and β2 integrin (CD-18). Pro-inflammatory cytokines up- regulate the expression of integrin receptors on endothelial cells, such as intracellular adhesion molecules and vascular adhesion molecules, causing adhesion of neutrophils to endothelial cells. Activation of endothelial cells by pro-inflammatory cytokines also increases the production of nitric oxide (NO) via inducible nitric oxide synthase. Neutrophils result in further tissue damage through the production of reactive oxygen intermediates. The addition of NO to the reactive oxygen intermediate results in the formation of peroxynitrite, which further causes cell damage. TNF Marker Antibodies IVD antibodies are extensively used for disease screening, therapeutic monitoring, and immunology methods such as immunonephelometry and sandwich ELISA. Through our role as a leading antibody IVD company, Creative Biolabs is well-positioned to deliver a focused product to the research market representing the highest value targets for the diagnosis and prognosis of liver failure and sepsis. Creative Biolabs has focused on IVD antibodies discovery for years. We have experts who are able to develop high-affinity IVD antibodies against varies of markers. We are therefore confident in offering the most suitable service and finest results for our customers all over the world. If you are interested in our IVD antibodies discovery services, please contact us for more details. Reference 1. Yun Dong, (2015) “Targeting of Tumor Necrosis Factor Alpha Receptors as a Therapeutic Strategy for Neurodegenerative Disorders” Antibodies 4(4), 369- 408. Related Services: IVD Antibody Development Services for IL-18 Marker IVD Antibody Development Services for IL-10 IVD Antibody Development Services for Gro-alpha Marker IVD Antibody Development Services for IL-1 Receptor Antagonist Marker IVD Antibody Development Services for IL-1β Marker IVD Antibody Development Services for IL-2 Marker IVD Antibody Development Services for IL-4 Marker IVD Antibody Development Services for IL-5 Marker IVD Antibody Development Services for IL-13 Marker IVD Antibody Development Services for MIP-1 Marker

  4. IVD Antibody Development Services for MIP-2 Marker IVD Antibody Development Services for MIF Marker IVD Antibody Development Services for MCP-1 Marker IVD Antibody Development Services for MCP-2 Marker IVD Antibody Development Services for Osteopontin Marker IVD Antibody Development Services for RANTES Marker IVD Antibody Development Services for CD10 Marker IVD Antibody Development Services for CD11b Marker IVD Antibody Development Services for CD11c Marker IVD Antibody Development Services for CD14 Marker IVD Antibody Development Services for CD28 Marker IVD Antibody Development Services for CD40 Marker IVD Antibody Development Services for CD64 Marker IVD Antibody Development Services for CD80 Marker IVD Antibody Development Services for CD163 Marker IVD Antibody Development Services for mHLA-DR Marker IVD Antibody Development Services for CCR3 Marker IVD Antibody Development Services for RAGE Marker IVD Antibody Development Services for TLR2 Marker IVD Antibody Development Services for TLR4 Marker IVD Antibody Development Services for TREM-1 Marker IVD Antibody Development Services for uPAR Marker IVD Antibody Development Services for Antithrombin Marker IVD Antibody Development Services for aPTT Marker IVD Antibody Development Services for TAT Marker IVD Antibody Development Services for F1.2 Marker IVD Antibody Development Services for PF-4 Marker IVD Antibody Development Services for Protein C Marker IVD Antibody Development Services for Thrombomodulin Marker IVD Antibody Development Services for ELAM-1 Marker IVD Antibody Development Services for cEPCs Marker IVD Antibody Development Services for Neopterin Marker IVD Antibody Development Services for PDGF-BB Marker IVD Antibody Development Services for E-Selectin Marker IVD Antibody Development Services for L-Selectin Marker IVD Antibody Development Services for VEGF Marker IVD Antibody Development Services for vWF Antigen Marker IVD Antibody Development Services for ANP Marker IVD Antibody Development Services for Endothelin-1 Marker IVD Antibody Development Services for Protein S-100β Marker IVD Antibody Development Services for SAA Marker IVD Antibody Development Services for Ceruloplasmin Marker IVD Antibody Development Services for Gas-6 Marker IVD Antibody Development Services for HLA-G5 Protein Marker

  5. IVD Antibody Development Services for Lactate Marker IVD Antibody Development Services for Leptin Marker IVD Antibody Development Services for N/OFQ Marker IVD Antibody Development Services for NF-κB Marker IVD Antibody Development Services for Plasma Fibronectin Marker IVD Antibody Development Services for Renin Marker IVD Antibody Development Services for TIMP-1 Marker IVD Antibody Development Services for Urinary 8-OHdG Marker IVD Antibody Development Services for Xanthine Oxidase Marker IVD Antibody Development Services for Pro-ET-1 Marker IVD Antibody Development Services for β-thromboglobulin Marker IVD Antibody Development Services for Ceramide Marker IVD Antibody Development Services for Cholesterol Esters Marker IVD Antibody Development Services for Complement C3 Marker IVD Antibody Development Services for Complement C4 Marker IVD Antibody Development Services for Complement C5a Marker IVD Antibody Development Services for DC Marker IVD Antibody Development Services for Diiodotyrosine Marker IVD Antibody Development Services for Eicosanoid Marker IVD Antibody Development Services for Elastase Marker IVD Antibody Development Services for Elastase-α1-antitrypsin Marker IVD Antibody Development Services for Erythropoietin Marker IVD Antibody Development Services for F2 Isoprostanes Marker IVD Antibody Development Services for CRTh2 Marker IVD Antibody Development Services for Fas Receptor Marker IVD Antibody Development Services for Fc-γ RIII Marker IVD Antibody Development Services for ADAMTS-13 Marker IVD Antibody Development Services for Ang1 Marker IVD Antibody Development Services for Ang2 Marker IVD Antibody Development Services for Endocan Marker IVD Antibody Development Services for Ferritin Marker IVD Antibody Development Services for AGP Marker IVD Antibody Development Services for LBP Marker IVD Antibody Development Services for Procalcitonin Marker IVD Antibody Development Services for Pentraxin 3 Marker IVD Antibody Development Services for Apo CI Marker IVD Antibody Development Services for FAAH Marker IVD Antibody Development Services for G-CSF Marker IVD Antibody Development Services for GM-CSF Marker IVD Antibody Development Services for Gelsolin Marker

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