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Cardiothoracic and Vascular Anesthesia Department of Anesthesiology

Impact of Autologous Platelet Rich Plasma Transfusion On Clinical Outcomes in Descending Thoracic Abdominal Aortic Aneurysm Repair. S. Zhou, MD, A. Estrera, MD, T. LI, MD, C. Ignacio, MD, S. Panthayi, MD, H. Safi, MD, R. Sheinbaum, MD. Cardiothoracic and Vascular Anesthesia

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Cardiothoracic and Vascular Anesthesia Department of Anesthesiology

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  1. Impact of Autologous Platelet Rich Plasma Transfusion On Clinical Outcomes in Descending Thoracic Abdominal Aortic Aneurysm Repair S. Zhou, MD, A. Estrera, MD, T. LI, MD, C. Ignacio, MD, S. Panthayi, MD, H. Safi, MD, R. Sheinbaum, MD Cardiothoracic and Vascular Anesthesia Department of Anesthesiology The University of Texas Medical School at Houston

  2. Autologous Platelet Rich Plasma Harvesting Platelet Rich Plasma WB Collected by harvesting 15-20 ml/kg whole blood prior to CPB Fractionating off the PRP component. The goal was a yield of 10-15 ml/kg of aPRP. aPRP RBC

  3. Purpose aPRP was used to reestablish hemostasis and significantly reduce intra-operative transfusions Investigate the effect of aPRP transfusion on the clinical outcome of patients undergoing TAAA repair.

  4. Materials and Methods • Retrospectively reviewed 535 cases of TAAA repair • Ages 18-80, • From Feb. 2003 to July 2008. • 182 patients received aPRP harvest and 353 patients did not.

  5. Patient Demographics Demographics and surgical characteristic between two groups were similar.

  6. Intra-Operative Blood Transfusion Intra-Operative blood transfusions were significantly reduced in the aPRP cohort .

  7. Intra-Operative Blood Transfusion

  8. Results • In the PRP group 24/182 (13.2%) received no transfusions 134/182(73.6%) received no platelet transfusion 69/182(37.9%) required 4 or less units of PRBC transfusion

  9. Morbidity

  10. Time To Extubation The aPRP group also required reduced ventilator time and were extubated earlier

  11. Conclusions • Use of PRP in thoracic and thoracoabdominal aortic aneurysm repair resulted in reduced blood product utilization translating into improved morbidity and mortality. • Prospective randomized studies are required.

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