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Cardiothoracic and Vascular Anesthesia Department of Anesthesiology

Impact of Autologous Platelet Rich Plasma Transfusion On Clinical Outcomes In Ascending Aortic Surgery With Deep Hypothermic Circulatory Arrest. SF. Zhou, MD, A. Estrera, MD, T. LI, MD, C. Ignacio, MD, S. Panthayi, MD, H. Safi, MD, A.Chuang, Ph.D. R. Sheinbaum, MD.

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Cardiothoracic and Vascular Anesthesia Department of Anesthesiology

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  1. Impact of Autologous Platelet Rich Plasma Transfusion On Clinical Outcomes In Ascending Aortic Surgery With Deep Hypothermic Circulatory Arrest SF. Zhou, MD, A. Estrera, MD, T. LI, MD, C. Ignacio, MD, S. Panthayi, MD, H. Safi, MD, A.Chuang, Ph.D. R. Sheinbaum, MD Cardiothoracic and Vascular Anesthesia Department of Anesthesiology The University of Texas Medical School at Houston

  2. Autologous Platelet Rich Plasma Harvesting Platelet Rich Plasma WB Collected by harvesting 15-20 ml/kg whole blood prior to CPB Fractionating off the PRP component. The goal was a yield of 10-15 ml/kg of aPRP. aPRP RBC

  3. Purpose aPRP was used to reestablish hemostasis and significantly reduce intra-operative transfusions Investigate the effect of aPRP transfusion on the clinical outcome of patients undergoing aortic arch surgery with deep hypothermic circulatory arrest (DHCA)

  4. Materials and Methods • Retrospectively reviewed 454 cases of ascending aorta and arch repair with DHCA. • Ages 18-80, • From Feb. 2003 to Dec. 2008. • 200 patients underwent aPRP harvest and 254 patients did not.

  5. Patient Demographics

  6. Intra-OP transfusion

  7. Perioperative Blood Transfusion

  8. Results • In the PRP group 39/200 (19.5%) received no transfusions 129/200(64.5%) received no platelet transfusion 70/200(35%) required 4 or less units of transfusion

  9. Post-Operative Complications

  10. Discharge Outcome

  11. Morbidity

  12. Conclusions • Use of aPRP in ascending arch repair with DHCA surgery resulted in reduced morbidity and mortality. • Prospective randomized controlled studies are required.

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