Stability and Reactivity Study of Migrant Components in Food Packaging Inks and Adhesives
This study investigates the stability and reactivity of migrant components from printing inks and adhesives used in food packaging. It covers classical migration methods, including diffusion through direct contact and gas phase migration. Comprehensive assessments are presented, including a risk ranking of various compounds based on their migration potential and toxicity. The research is crucial for ensuring the safety of food contact materials. The findings align with PR FAVV-AFSCA 2009/01 regulations, aimed at establishing harmonized safety standards in food packaging.
Stability and Reactivity Study of Migrant Components in Food Packaging Inks and Adhesives
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Presentation Transcript
Study of the stability and reactivity of migrant migrant components from printing inks and adhesives, used in packaging materials of foodstuffs - MIGRINKT.
Overview • Introduction • PR FAVV-AFSCA 2009/01 • MIGRINKT • Overview 6 WP • WP 1 (15th of March) • Today
Introduction: Migration food • Classicalmigration (diffusion) • Via direct contact • Via gas phase • Unintentedpresence (set-off and residuesof technical aids) GMP food
Overview • Introduction • PR FAVV-AFSCA 2009/01 • MIGRINKT • Overview 6 WP • WP 1 (15th of March) • Today
PR FAVV-AFSCA 2009/01 • No harmonizedlegislation !!! • General list
PR FAVV-AFSCA 2009/01 –General list of compounds usedforinksandgluesmanufacture Swiss Ordinance on Food Contact materials 817.023.21 • 1stof April 2010 • Annex 1 (List I and II of EC Plastic Directive 2002/72/EC) and Annex 6 (List I-V) • Annex 6 lists 5 groups of substances (almost 6000 comp) • Monomers • Colorants • Solvents • Additives • Photoinitiators List A: evaluatedsubstances, sufficienttoxicity data (SML based on TDIvalue) List B: “unevaluated” substances, insufficienttoxicity data (10ppb or lowerdetection limit)
PR FAVV-AFSCA 2009/01 –General list of compounds usedforinksandglues manufacturing • All compounds listed in the Annex 6 of the Swiss Ordinance (Lists A and B) (5760 comp in total) • Missing substances listed in the Information letter to the Swiss Ordinance (218 compounds) • Compounds from Plastic Directive 2002/72/EC (Annex 1 of the Swiss Ordinance) not included in the Annex 6 of the Swiss Ordinance (65 compounds) • Compounds from FACET list not included in the Annex 6 of the Swiss Ordinance (54 compounds)
PR FAVV-AFSCA 2009/01 • General list Final list 6097 399 compounds • Final list risk ranking list: • MW • SML
MW < medianvalue (202 Da) low MW highest priority 104 compounds low SML 207 compounds high MW 103 compounds medianvalue (202 Da) MW < medianvalue (1 mg/kg food) SML £ middle priority 399 compounds MW medianvalue (184 Da) < medianvalue (1 mg/kg food) > SML low MW 96 compounds high SML high MW 192 compounds lowest priority 96 compounds MW < medianvalue (184 Da) PR FAVV-AFSCA 2009/01 – Final list Risk ranking list
MW < medianvalue (202 Da) low MW highest priority 104 compounds low SML 207 compounds high MW 103 compounds medianvalue (202 Da) MW < medianvalue (1 mg/kg food) SML £ middle priority 399 compounds MW medianvalue (184 Da) < medianvalue (1 mg/kg food) > SML low MW 96 compounds high SML high MW 192 compounds lowest priority 96 compounds MW < medianvalue (184 Da) PR FAVV-AFSCA 2009/01 – Final list Risk ranking list • This list includes: • 27 additives • 60 monomers • 2 solvents • 5 photoinitiators • 10 compounds from Plastic Directive
Overview • Introduction • PR FAVV-AFSCA 2009/01 • MIGRINKT • Overview 6 WP • WP 1 (15th of March) • Today
MIGRINKT – overview 6WP • WP 1: Study of literature concerning stability, reactivity and analyze methods of the most relevant migrants • WP 2, 3 & 4: Study of stabilityselected migrants in water and acetic acid (WP2), ethanol (WP3) and MPPO (WP4) • Not UV-activated compounds • UV-activated compounds
WP 2, 3 & 4 : Not UV-activated compounds 10 days/40°C 24h/reflux Light Dark Light Dark 100% recovery ? yes OK no Investigation differenttemperatures (20 – 60°C) and times (1 – 10 days)
WP 2, 3& 4 : UV-activated compounds UV-activation No UV-activation 10 days/40°C 24h/reflux 10 days/40°C 24h/reflux Light Dark Light Dark Light Dark Light Dark 100% recovery ? yes OK no Investigation differenttemperatures (20 – 60°C) and times (1 – 10 days)
MIGRINKT – overview 6WP • WP 1: Study of literature concerning stability, reactivity and analyze methods of the most relevant migrants • WP 2, 3 & 4: Study of stabilityselected migrants in water and acetic acid (WP2), ethanol (WP3) and MPPO (WP4) • WP 5: Validationkinetic models withpackaging film • WP 6: General coordinationand reports
MW < medianvalue (202 Da) low MW highest priority 104 compounds low SML 207 compounds high MW 103 compounds medianvalue (202 Da) MW < medianvalue (1 mg/kg food) SML £ middle priority 399 compounds MW medianvalue (184 Da) < medianvalue (1 mg/kg food) > SML low MW 96 compounds high SML high MW 192 compounds lowest priority 96 compounds MW < medianvalue (184 Da) MIGRINKT – WP1Risk ranking list FAVV
MIGRINKT – WP1Photoinitiators • High priority (5): Benzophenone 2-methylbenzophenone 3-methylbenzophenone 4-methylbenzophenone Ethyl-4-(dimethylamino)benzoate • Middle priority (7): Methyl-2-benzoylbenzoate 2-Isopropyl thioxanthone 4-Isopropyl thioxanthone 2-Benzyl-2-dimethylamino-4-morpholino butyrophenone 2-(4-Methylbenzyl)-2-dimethylamino-1-(4-morpholinophenyl)-1-butanon 2-Hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)benzyl)phenyl-2-methyl-2-propanone 1-(4-[(4-Benzoylphenyl)thio]phenyl)-2-methyl-2-[(4-methylphenyl)sulfonyl]-1-propan-1-one
MIGRINKT – WP1Photoinitiators • High priority (5): Benzophenone 2-methylbenzophenone – Type II 3-methylbenzophenone – Type II 4-methylbenzophenone – Type II Ethyl-4-(dimethylamino)benzoate – Type I and coinitiator • Middle priority (7): Methyl-2-benzoylbenzoate – Type II 2-Isopropyl thioxanthone – Type II 4-Isopropyl thioxanthone – Type II 2-Benzyl-2-dimethylamino-4-morpholino butyrophenone – Type I 2-(4-Methylbenzyl)-2-dimethylamino-1-(4-morpholinophenyl)-1-butanon 2-Hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)benzyl)phenyl-2-methyl-2-propanone – Type I 1-(4-[(4-Benzoylphenyl)thio]phenyl)-2-methyl-2-[(4-methylphenyl)sulfonyl]-1-propan-1-one – Type I
Overview • Introduction • PR FAVV-AFSCA 2009/01 • MIGRINKT • Overview 6 WP • WP 1 (15th of March) • Today: Questions
Are any of the selectedphotoinitiators (still) used in ink/glue-manufacturing? • High priority (5): Benzophenone 2-methylbenzophenone – Type II 3-methylbenzophenone – Type II 4-methylbenzophenone – Type II Ethyl-4-(dimethylamino)benzoate – Type I and coinitiator • Middle priority (7): Methyl-2-benzoylbenzoate – Type II 2-Isopropyl thioxanthone – Type II 4-Isopropyl thioxanthone – Type II 2-Benzyl-2-dimethylamino-4-morpholino butyrophenone – Type I 2-(4-Methylbenzyl)-2-dimethylamino-1-(4-morpholinophenyl)-1-butanon 2-Hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)benzyl)phenyl-2-methyl-2-propanone – Type I 1-(4-[(4-Benzoylphenyl)thio]phenyl)-2-methyl-2-[(4-methylphenyl)sulfonyl]-1-propan-1-one – Type I
Are any of the selectedcoinitiators(still) used in ink/glue-manufacturing? • Ethyl-4-(dimethylamino)benzoate • 4,4’-bis(dimethylamino)benzophenone) CAS: 90-93-7 • 1-hydroxycyclohexyl-1-phenyl ketone CAS: 947-19-3 • 2-ethylhexyl-4-dimethylaminobenzoate CAS: 21245-02-3 • 2-methyl-1(4-(methylthio)phenyl)-2-morpholino propan-1-one CAS: 71868-10-5
Solvents are usedin ink/glue-manufacturing? • Ethyl acetate? • Ethanol?
UV-radiation? • Glue: 300-500nm • Ink: 365-400nm 365nm? • Light intensity range: 50-5000mW/cm2 Narrow down?
Practical questions? • Contact? • E.g. Mixture of • Photoinitiator • Coinitiator • Solvent concentrations?
