1 / 2

PPAR Signaling Pathway

PPAR Signaling Pathway. SIGMA-ALDRICH. PPAR Signaling Pathway

betty
Télécharger la présentation

PPAR Signaling Pathway

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. PPAR Signaling Pathway SIGMA-ALDRICH

  2. PPAR Signaling Pathway Similar to other nuclear hormone receptors, peroxisome proliferator-activated receptors (PPARs) act as ligand-activated transcription factors. When bound to its fatty acid ligand, PPAR forms a heterodimeric complex with the retinoid X receptor (RXR) to regulate transcription. PPAR is activated by prostaglandins and leukotrienes and regulates the gene expression of proteins involved in the storage of fatty acids. PAR is weakly activated by fatty acids, prostaglandins, and leukotrienes. Its physiological ligand has not been identified. References Fajas, L., et al., Peroxisome proliferator-activated receptor-  : from adipogenesis to carcinogenesis. J. Mol. Endocrinol., 27, 1-9 (2001). Qi, C., et al., Peroxisome proliferator-activated receptors, coactivators, and downstream targets. Cell. Biochem. Biophys., 32, 187-204 (2000).

More Related