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NON-DIABETIC WOMEN

NON-DIABETIC MEN. Chol/HDL. Chol/HDL. Chol/HDL. Chol/HDL. Age 70. Age 70. Chol/HDL. Chol/HDL. Chol/HDL. Chol/HDL. Age 60. Age 60. Chol/HDL. Chol/HDL. Chol/HDL. Chol/HDL. Age 50. Age 50. Chol/HDL. Chol/HDL. Chol/HDL. Chol/HDL. Age 40. Age 40. Chol/HDL. Chol/HDL.

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NON-DIABETIC WOMEN

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  1. NON-DIABETIC MEN Chol/HDL Chol/HDL Chol/HDL Chol/HDL Age 70 Age 70 Chol/HDL Chol/HDL Chol/HDL Chol/HDL Age 60 Age 60 Chol/HDL Chol/HDL Chol/HDL Chol/HDL Age 50 Age 50 Chol/HDL Chol/HDL Chol/HDL Chol/HDL Age 40 Age 40 Chol/HDL Chol/HDL Chol/HDL Chol/HDL Age 30 Age 30 NON-SMOKERS NON-SMOKERS SMOKERS SMOKERS 4 5 6 7 5 6 7 8 5 6 7 8 4 5 6 7 180 180 180 180 160 160 160 160 SBP SBP SBP SBP 140 140 140 140 120 120 120 120 NON-DIABETIC WOMEN 5 6 7 8 5 6 7 8 4 5 6 7 4 5 6 7 180 180 180 180 160 160 160 160 SBP SBP SBP SBP 140 140 140 140 120 120 120 120 5 6 7 8 5 6 7 8 4 5 6 7 4 5 6 7 180 180 180 180 160 160 160 160 SBP SBP SBP SBP 140 140 140 140 120 120 120 120 5 6 7 8 5 6 7 8 4 5 6 7 4 5 6 7 180 180 180 180 160 160 160 160 SBP SBP SBP SBP 140 140 140 140 120 120 120 120 5 6 7 8 5 6 7 8 4 5 6 7 4 5 6 7 180 180 180 180 160 160 160 160 SBP SBP SBP SBP 140 140 140 140 120 120 120 120 % Risk of CHD event in 10 yrs <5% 5-10% 10-20% 20-40% 40-60%

  2. 70% 60% 50% 40% 30% 20% 15% 10% 7.5% 5% 2.5% Background risk per 10 years Effect of treatment on events per 100 subjects per 10 years Reduction in events per 100 subjects per 10 years Numbers needed to treat for 10 years to prevent one event 80% 60% 20 5 53% 17.5 6 45% 15 6.7 38% 12.5 8 30% 10 10 23% 7.5 13.3 15% 5 20 11% 3.75 26.7 8% 2.5 40 6% 1.87 53.3 4% 1.25 80 2% 0.53 160

  3. Chol/HDL Chol/HDL Chol/HDL Chol/HDL Age 70 Age 70 Chol/HDL Chol/HDL Chol/HDL Chol/HDL Age 60 Age 60 Chol/HDL Chol/HDL Chol/HDL Chol/HDL Age 50 Age 50 Chol/HDL Chol/HDL Chol/HDL Chol/HDL Age 40 Age 40 Chol/HDL Chol/HDL Chol/HDL Chol/HDL Age 30 Age 30 Chol/HDL Chol/HDL NORMOALBUMINURIC DIABETIC MEN NON-SMOKERS NON-SMOKERS SMOKERS SMOKERS 4 5 6 7 5 6 7 8 5 6 7 8 4 5 6 7 180 180 180 180 160 160 160 160 SBP SBP SBP SBP 140 140 140 140 NORMOALBUMINURIC DIABETIC WOMEN 120 120 120 120 5 6 7 8 5 6 7 8 4 5 6 7 4 5 6 7 180 180 180 180 160 160 160 160 SBP SBP SBP SBP 140 140 140 140 120 120 120 120 5 6 7 8 5 6 7 8 4 5 6 7 4 5 6 7 180 180 180 180 160 160 160 160 SBP SBP SBP SBP 140 140 140 140 120 120 120 120 5 6 7 8 5 6 7 8 4 5 6 7 4 5 6 7 180 180 180 180 160 160 160 160 SBP SBP SBP SBP 140 140 140 140 120 120 120 120 5 6 7 8 5 6 7 8 4 5 6 7 4 5 6 7 180 180 180 180 160 160 160 160 SBP SBP SBP SBP 140 140 140 140 120 120 120 120 <5% 5-10% % Risk of CHD event in 10 yrs 10-20% 20-40% 40-60%

  4. Chol/HDL Chol/HDL Chol/HDL Chol/HDL Age 70 Age 70 Chol/HDL Chol/HDL Chol/HDL Chol/HDL Age 60 Age 60 Chol/HDL Chol/HDL Chol/HDL Chol/HDL Age 50 Age 50 Chol/HDL Chol/HDL Chol/HDL Chol/HDL Age 40 Age 40 Chol/HDL Chol/HDL Chol/HDL Chol/HDL Age 30 Age 30 MICROALBUMINURIC DIABETIC MEN NON-SMOKERS NON-SMOKERS SMOKERS SMOKERS 4 5 6 7 5 6 7 8 5 6 7 8 4 5 6 7 180 180 180 160 160 160 SBP SBP 140 140 140 180 120 120 120 MICROALBUMINURIC DIABETIC WOMEN 160 SBP SBP 140 5 6 7 8 5 6 7 8 4 5 6 7 4 5 6 7 120 180 180 180 160 160 160 SBP SBP 140 140 140 180 120 120 120 160 SBP SBP 140 5 6 7 8 5 6 7 8 4 5 6 7 4 5 6 7 120 180 180 180 160 160 160 SBP SBP 140 140 140 180 120 120 120 160 SBP SBP 140 5 6 7 8 5 6 7 8 4 5 6 7 4 5 6 7 120 180 180 180 160 160 160 SBP SBP 140 140 140 180 120 120 120 160 SBP SBP 140 5 6 7 8 5 6 7 8 4 5 6 7 4 5 6 7 120 180 180 180 160 160 160 SBP SBP 140 140 140 180 120 120 120 160 SBP SBP 140 <5% 120 5-10% 10-20% % Risk of CHD event in 10 yrs 20-40% 40-60%

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