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Investigating “Gene Ontology”-based semantic similarity in the context of functional genomics

Investigating “Gene Ontology”-based semantic similarity in the context of functional genomics. Dani Welter, PhD student, COMSC 10-12-2010. The project. Development of a grouping algorithm that incorporates both GO terms and gene products.

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Investigating “Gene Ontology”-based semantic similarity in the context of functional genomics

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  1. Investigating “Gene Ontology”-based semantic similarity in the context of functional genomics Dani Welter, PhD student, COMSC 10-12-2010

  2. The project • Development of a grouping algorithm that incorporates both GO terms and gene products. • Using existing semantic and functional similarity approaches to group gene products based on their GO annotation

  3. Aims • Identification of functionally related gene products with respect to the functional aspect that they are related on • Exploitation of functional annotation data independently of other forms of biological similarity

  4. Difference to existing approaches • Gene products can be in multiple groups  less restrictive than most clustering approaches • Takes into account that a gene product can have multiple functional relationships with other gene products

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