Inhibition of Autophagy Induces Cellular Pathway Alterations in Various Signaling Pathways

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This study investigates the impact of 3-MA treatment on key proteins involved in autophagic and cellular signaling pathways in cell cultures. Analysis includes measuring alterations in mTOR, p53, HIF-1α, and other associated factors.

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Mar 01, 2025

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Inhibition of Autophagy Induces Cellular Pathway Alterations in Various Signaling Pathways

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Figure S6 (mM) 3-MA – – 5 5 – – 5 5 – – 5 MLN – 0.05 – 0.05 – 0.05 – 0.05 1.0 1.0 1.0 (µM) CBS (nM) – – – – 100 100 100 100 – 100 100 CRM1 CulNEDD8 Cullins p53 HIF-1 S6K p-S6K LC3-I LC3-II p62 1.0 1.0 1.3 2.3 3.0 1.8 3.9 1.9 0.8 1.6 2.4 -actin