'P53' diaporamas de présentation

The Anti-Tumor Function and Signal Transduction Pathway of p53 Protein

The Anti-Tumor Function and Signal Transduction Pathway of p53 Protein. Introduction.

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NITRIC OXIDE

NITRIC OXIDE. Aseem Hussain. NITRIC OXIDE. Nitric oxide is a gas. It is highly reactive; and is one of the products in automobile exhaust and plays a major role in atmospheric pollution. Surprisingly, it was found that it has important physiological functions. NITRIC OXIDE.

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p53 - guardian or the genome

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Gene regulation in cancer

Gene regulation in cancer. 11/14/07. Overview. The hallmark of cancer is uncontrolled cell proliferation. Oncogenes code for proteins that help to regulate cell growth and differentiation. A mutation in an oncogene causes uncontrolled cell growth.

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CASE 17

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CHMI 4237 E Special topics in Biochemistry

CHMI 4237 E Special topics in Biochemistry. Cell proliferation 2- cell cycle checkpoints. Eric R. Gauthier, Ph.D . Dept . Chemistry - Biochemistry Laurentian University. 1) How does the basic cell cycle machinery work?

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Case Study 18

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MOLECULAR CARCINOGENESIS

MOLECULAR CARCINOGENESIS. Defects in Terminal Differentiation Defects in Growth Control Resistance to Cytotoxicity Defects in Programmed Cell Death. CHEMICAL. Body Surface. R A D I A T I O N. Excretion. Deactivation. Selective Clonal Expansion. Genetic Change. Genetic

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Overview of the Lectures

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Cell Growth & Differentiation Vol. 10, 545-554, 1999

Cell Growth & Differentiation Vol. 10, 545-554, 1999 Inhibition of the Jun Kinase Pathway Blocks DNA Repair, Enhances p53-mediated Apoptosis and Promotes Gene Amplification Ruth A. Gjerset, Svetlana Lebedeva, Ali Haghighi, Sally T. Turla and Dan Mercola. Two independent experiment system.

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Supp. Table I

Supp. Table I. Dearth et al. 5. Supp. Table II. Dearth et al. 6. Supp. Fig. 1. Dearth et al. 7. A. wt p53. p53 DBS. p53 mutant. p53 DBS. p53. ADH1. URA3. p53mut. ADH1. CEN. LEU2. CEN. HIS3. CEN. TRP1. URA3. CEN. TRP1. MAT a. MAT a. MAT a. p53. ADH1. p53mut.

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Fig. 1

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Authors: Stadler WM et al, ASCO 2009. Reviewed by: Dr. Lori Wood Abstract: 5017

Randomized Trial of p53 Targeted Adjuvant Therapy for Patients (pts) With Organ-Confined Node-Negative Urothelial Bladder Cancer (UBC). Authors: Stadler WM et al, ASCO 2009. Reviewed by: Dr. Lori Wood Abstract: 5017 Date posted: June 12, 2009. Treatment A: Adjuvant MVAC x 3. R.

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P04637|Human KGEPHHELPPGSTKRALPNNTSS S PQPKKKPLDGEYFTLQIRGRERFEMFRE

315. P04637|Human KGEPHHELPPGSTKRALPNNTSS S PQPKKKPLDGEYFTLQIRGRERFEMFRE P56424|Rhesus KGEPCHQLPPGSTKRALPNNTSS S PQPKKKPLDGEYFTLQIRGRERFEMFRE

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RNAi

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p53

p53. Ki-67.

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H+E p53

a. H+E p53. Cre+Apc fl/fl P53 +/+. b. QRT-PCR expression of P53. 2.5. *. 2. 1.5. Fold Change. 1. *. *. 0.5. WT ApcFlox Double P53null. 0.

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