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Biophysical Immunology Laboratory

Biophysical Immunology Laboratory. Thomas Vorup-Jensen. Institute for Medical Microbiology and Immunology University of Aarhus Denmark vorup-jensen@microbiology.au.dk. B-cell activation and Ab production Janeway’s Immunobiology Chapter 10 Cellular and humoral factors .

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Biophysical Immunology Laboratory

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  1. Biophysical Immunology Laboratory Thomas Vorup-Jensen Institute for Medical Microbiology and Immunology University of Aarhus Denmark vorup-jensen@microbiology.au.dk

  2. B-cellactivation and Ab production Janeway’sImmunobiologyChapter10 Cellular and humoral factors Important messanges: B cells are activated in T cell dependent and independent processes Presentation of antigens to T cells by B cells Structure and function of antibodies

  3. I II III

  4. (CD8+ T cellsarealso Important for clearance of virus!!)

  5. (See Chapter 6 on Ag presentation)

  6. How to facilitate an Ab response to carbohydrateAgs ?!

  7. T cell APC

  8. Structural basis for allosteric ligand binding in integrins Xiao et al. (2004) Nature432:59-67

  9. Signalling occurs by redistribution of kinases and phosphotases in cell-cell contact.

  10. B-cellactivation and Ab production Janeway’sImmunobiologyChapter10 Cellular and humoral factors Important messanges: Cytokine environment is important B cell differentiation. T cells contribute to the cytokine production. Signaling in T cell are regulated by formation of the immunological Synapse.

  11. Dendriticcells: a veiledmembranethatpermitsefficientadhesion to lymphocytes? K. Inabaet al., J. Exp. Med. (1984) 160:858

  12. Macrophages (MØ) produce more proteases thandendriticcellsor B lymphocytes AEP: asparagineendopeptidase; cat:cathepsin Delamarreet al. Science (2005) 307:1630-1634

  13. B-cellactivation and Ab production Janeway’sImmunobiologyChapter10 Cellular and humoral factors Important messanges: Lymph nodes are central in B cell differentiation. T and B cells occupy distinct zones in this tissue

  14. (See Chapter 5 on geneticregulation Ab mRNAtranscription and editing)

  15. B-cellactivation and Ab production Janeway’sImmunobiologyChapter10 Cellular and humoral factors Important messanges: The antibody production is regulated with regard to isotype and clonality in response to microbial products

  16. B-cellactivation and Ab production Janeway’sImmunobiologyChapter10 Cellular and humoral factors Important messanges: Antibodies (immunoglobulins) posses different functionalities Antibodies are actively transported to distinct location in the body

  17. B-cellactivation and Ab production Janeway’sImmunobiologyChapter10 Cellular and humoral factors Important messanges: Antibody effectormeachnisms (I): Antibodies may act to neutralize functions of microbial molecules (sometimes a trouble in drug treatment!)

  18. ”Target-binding” complement proteins arelargerthan the rest…. …but why? Tanakaet al. (2010) 35 nm Vorup-Jensen & Boesen (2011) Adv. Drug Discov. Rev. 63:1008-19 J Infect Chemother16:383–387

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