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Diagnostic Challenge: Diffuse Large B-Cell Lymphoma in a 56-Year-Old Woman

A 56-year-old woman presented with a seizure, revealing multiple brain masses, notably in the temporal lobe. After an unexpected cardiac event prior to a scheduled stereotactic biopsy, an autopsy was conducted. Histological examination indicated a diffuse large B-cell lymphoma, characterized by atypical lymphocytes and an expanded reticulin network. Immunohistochemical profiling showed CD20(+) and CD79a(+) B-cell lineage markers, confirming the diagnosis. This case illustrates the importance of recognizing CNS lymphoma, even in immunocompetent individuals of advanced age.

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Diagnostic Challenge: Diffuse Large B-Cell Lymphoma in a 56-Year-Old Woman

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  1. Diagnostic ChallengePathology for Neurosurgery & Neurology ResidentsDepartment of PathologyUniversity of Oklahoma Health Sciences Center,Oklahoma City, OK, U.S.A. Case 13 History: The patient was a 56 year-old woman who presented with a seizure. She was admitted to the hospital and multiple mass was found in her brain with the largest one in the temporal lobe. She was otherwise free other manifestations or constitutional symptoms. A stereotactic biopsy was scheduled but she died unexpectedly of cardiac problem a day before the planned procedure. An autopsy was performed. The followings are representative images. Contributor: Kar-Ming Fung, M.D., Ph.D., karming-fung@ouhsc.edu Last updataded: 3/6/2009

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  3. Reticulin B C Immunohistochemistry: The large cells are CD20 (+), CD79a (+), and CD3 (-). D

  4. What is your diagnosis?

  5. Diagnosis: Diffuse large B-cell type lymphoma. Discussion: The histologic features are highly characteristic for a diffuse large B-cell lymphoma. The features include concentric perivascularinfiltrating large and atypical lymphocytes with expansion of the reticulin network (inset below). The lumen of the blood vessels are indicated by the arrows below. The immunohistochemical profile indicates a B-cell lineage (positive for CD20 and CD79a but negative for CD3).

  6. Multiple lesions (arrows) are present in the gross specimen, a classic finding of primary CNS lymphoma. The hemorrhage in the largest lesion, however, is not always present in lymphoma cases. The patient is not immunocompromised. It should be noted that primary CNS lymphoma can occur in immunocompetent host in the older age group. Those occurring in the immunocomprimised patient often, but not always, occur in younger patients.

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