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Comparative Morphology of SW480 and SW620 CRC Cells in Culture

This study presents a comparative analysis of the morphologies of SW480 and SW620 colorectal cancer (CRC) cell lines grown on standard cell culture plastic. The images depict cells approximately 60 hours post-passaging, at identical magnifications. Notably, SW480 cells, obtained from primary tumor tissues, exhibit a more adherent morphology, while SW620 cells, sourced from a lymph node metastasis of the same patient, are generally smaller and display a spindle-like shape. Such morphological transformations are also observed in fibroblasts post-SFK transformation.

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Comparative Morphology of SW480 and SW620 CRC Cells in Culture

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  1. SW480 SW620 Additional file 1 Comparison of SW480 and SW620 CRC cell morphologies Cells are grown on cell culture plastic without extra coating. Both images were taken ca. 60 h after cell passaging and are shown at the same magnification. The SW480 cells, which are derived from primary tumor tissue appear more attached. SW620 cells, derived from a lymph node metastasis of the same patient appear to be on average smaller and more spindle shaped. Similar morphological changes are, for example, also observed with fibroblasts upon transformation by SFK.

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