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Katie McAllister PhD Candidate Bussey-Saksida Cognitive Systems Neuroscience Lab

The TUNL task: A measure of working memory and pattern separation. Katie McAllister PhD Candidate Bussey-Saksida Cognitive Systems Neuroscience Lab The University of Cambridge. Delayed Non-Matching to Position (DNMTP). Widely used measure of spatial working memory ( Dunnett 1985).

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Katie McAllister PhD Candidate Bussey-Saksida Cognitive Systems Neuroscience Lab

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  1. The TUNL task: A measure of working memory and pattern separation Katie McAllister PhD Candidate Bussey-Saksida Cognitive Systems Neuroscience Lab The University of Cambridge

  2. Delayed Non-Matching to Position (DNMTP) Widely used measure of spatial working memory (Dunnett 1985)

  3. Rats cheat! Chudasama & Muir (1997)

  4. Trial-Unique Non-Matching to Location (TUNL) Sample Phase Talpos, McTighe, Dias, Bussey & Saksida (2010) Neurobiology of Learning and Memory

  5. Trial-Unique Non-Matching to Location (TUNL) Choice Phase

  6. Manipulate Working Memory

  7. Manipulate Pattern Separation

  8. Mediating Behaviours Not Observed Talpos, McTighe, Dias, Bussey & Saksida (2010) Neurobiology of Learning and Memory

  9. Hippocampal lesions cause delay- and separation-dependent impairments in TUNL Large Small Large Small Talpos, McTighe, Dias, Bussey & Saksida (2010) Neurobiology of Learning and Memory

  10. PFC lesions cause delay-dependent impairments in TUNL * No delay 6 second delay McAllister, Saksida, Bussey, Unpublished data

  11. PFC lesions do not cause separation-dependent impairments in TUNL Large separation Smaller separation McAllister, Saksida, Bussey, Unpublished data

  12. PFC lesions do not cause separation-dependent impairments in TUNL Very small separation Adjacent McAllister, Saksida, Bussey, Unpublished data

  13. The TUNL Task • Trial-unique method prevents mediating behaviours • Allows assessment of working memory, pattern separation, and the effects of interference • A part of the standardized task battery

  14. Thank You! Dr. Tim Bussey Dr. Lisa Saksida CSN Lab Members Funding was generously provided by Takeda Cambridge Ltd and the Cambridge Commonwealth Trusts.

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