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Cell Biology

Cell Biology. Outline. Organization of body systems Organ – Tissue – Cell — How do we study biology? Why should we? Research question in biology. Body System Hierarchy. System > Organ > Tissue > Cell. Body System Hierarchy. System > Organ > Tissue > Cell. Cardiovascular System.

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Cell Biology

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  1. Cell Biology

  2. Outline • Organization of body systems • Organ – Tissue – Cell— • How do we study biology? • Why should we? • Research question in biology

  3. Body System Hierarchy System > Organ > Tissue > Cell

  4. Body System Hierarchy System > Organ > Tissue > Cell Cardiovascular System

  5. Body System Hierarchy System > Organ > Tissue > Cell Cardiovascular System Blood Vessel (Organ) Vessel Tissue

  6. The functional part of organs are cells + matrix System > Organ > Tissue > Cell Blood Vessel Tissue Cells + Matrix Matrix are proteins that hold cells together and give tissues mechanical integrity

  7. The functional part of organs are cells + matrix Example: bone tissue Matrix Cells Matrix

  8. The functional part of organs are cells + matrix Example: bone tissue Matrix Cells Matrix Blood vessels

  9. The Cell

  10. The Cell This is not a cell…so what is it? ~3 um 50 um ~100 nm ~6 um ~5 um ~7 um

  11. What can cells do? Adhesion Change Shape (Spread) Cell Matrix Migrate Communicate Direction of Migration Hi Hey Actin Focal Adhesion

  12. How do we study Biology? In vitro In vivo Within glass Within the living

  13. Why do we study Biology? In vitro In vivo If we understand why cells malfunction, we can learn how to fix them

  14. Research Question: What role does matrix stiffness have on cells? Stress Shielding Cancer

  15. Let’s look at an experiment on single cells 50 um 50 um 50x10-6 m 50x10-6 m 1,000 Pascals 1 kPa 10,000 Pascals 10 kPa

  16. Substrate Stiffness Affects Cell Size 50 um 50 um 50x10-6 m 50x10-6 m 1,000 Pascals 1 kPa 10,000 Pascals 10 kPa

  17. Cell Proliferation (cell division) Cell Nucleus (DNA)

  18. What’s in cells? Proteins run the show Example: Structural proteins give cells shape

  19. What’s in cells? Proteins run the show Other proteins do lots of other things

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