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Antibiotics – antibiotic resistance 1) is the cell sensitive? - cell wall / membrane permeable?

Antibiotics – antibiotic resistance 1) is the cell sensitive? - cell wall / membrane permeable? - sensitive target present? 2) action at - cell wall synthesis - membrane functions - replication - transcription - translation

brittany-wynn
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Antibiotics – antibiotic resistance 1) is the cell sensitive? - cell wall / membrane permeable?

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  1. Antibiotics – antibiotic resistance 1) is the cell sensitive? - cell wall / membrane permeable? - sensitive target present? 2) action at - cell wall synthesis - membrane functions - replication - transcription - translation 3) resistance mechanism (nb. sometimes different mechanisms may be possible with the same antibiotic) - block penetration of the cell (keep the cell free of antibiotic) - degradation of the antibiotic (removal intra- or extracellularly) - modification of the antibiotic (inactivate the agent) - modification of the target (avoid the action) - amplification of the target (titration of the agent : tolerance by excess target)

  2. Dot-blot analysis of interferon-beta mRNA concentration.

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