1 / 15

Erica M. Holt, MPH : University of Minnesota (UM) Lyn M. Steffen, PhD, MPH, RD: UM

Fruit and Vegetable Consumption and its Relation to Markers of Inflammation and Oxidative Stress in Adolescents and Oxidative Stress in Adolescents. Erica M. Holt, MPH : University of Minnesota (UM) Lyn M. Steffen, PhD, MPH, RD: UM Antoinette Moran, MD: UM

byron-mccullough
Télécharger la présentation

Erica M. Holt, MPH : University of Minnesota (UM) Lyn M. Steffen, PhD, MPH, RD: UM

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Fruit and Vegetable Consumption and its Relation to Markers of Inflammation and Oxidative Stress in Adolescentsand Oxidative Stress in Adolescents Erica M. Holt, MPH : University of Minnesota (UM) Lyn M. Steffen, PhD, MPH, RD: UM Antoinette Moran, MD: UM Samar Basu, PhD: Uppsala University Julia Steinberger, MD: UM Julie A. Ross, PhD: UM Ching-Ping Hong, MS: UM Alan R. Sinaiko, MD: UM JOURNAL OF THEAMERICAN DIETETICASSOCIATION Holt E, et al. J Am Diet Assoc. 2009; 109 (Mar).

  2. Fruit and Vegetable Consumption and its Relation to Markers of Inflammation and Oxidative Stress in Adolescents Background • Fruits and vegetables, foods rich in flavonoids and antioxidants, have been associated with lower risk of stroke, coronary heart disease, and markers of inflammation and oxidative stress in adults • Markers of inflammation and oxidative stress are predictors of coronary heart disease risk • It is unknown whether these markers are related to dietary flavonoid and antioxidant intake in youth. JOURNAL OF THEAMERICAN DIETETICASSOCIATION Holt E, et al. J Am Diet Assoc. 2009; 109 (Mar).

  3. Fruit and Vegetable Consumption and its Relation to Markers of Inflammation and Oxidative Stress in Adolescents Study Objective To determine whether greater intakes of fruit and vegetables, antioxidants, and total flavonoids are inversely associated with markers of inflammation and oxidative stress in adolescent boys and girls. JOURNAL OF THEAMERICAN DIETETICASSOCIATION Holt E, et al. J Am Diet Assoc. 2009; 109 (Mar).

  4. Fruit and Vegetable Consumption and its Relation to Markers of Inflammation and Oxidative Stress in Adolescents Study Methods • Study Design • Cross-sectional study conducted in 1996-2000 • Study Population • 304 adolescent girls and boys • Exclusions for analysis: • 19 students without dietary data • 285 adolescents included in analysis JOURNAL OF THEAMERICAN DIETETICASSOCIATION Holt E, et al. J Am Diet Assoc. 2009; 109 (Mar).

  5. Fruit and Vegetable Consumption and its Relation to Markers of Inflammation and Oxidative Stress in Adolescents Data Collection • Tanner stage assessed (I, II, III, IV, V) • Height and weight measured • Body mass index (BMI) calculated kg/m2 • Fasting blood sample obtained • Analyzed for markers of inflammation (C-reactive protein [CRP], tumor necrosis factor-alpha [TNF-a], interleukin-6 [IL-6], 15-keto-dihydro-PGF2a [PGF2a] and oxidative stress, 8-iso-F2a [F2-isoprostane]) • Dietary intake assessment • Willett 127-item food frequency questionnaire JOURNAL OF THEAMERICAN DIETETICASSOCIATION Holt E, et al. J Am Diet Assoc. 2009; 109 (Mar).

  6. Fruit and Vegetable Consumption and its Relation to Markers of Inflammation and Oxidative Stress in Adolescents Food Groups • Food intakes were grouped into selected food categories for these analyses • Fruit: 10 different fruits • Fruit juice: apple, orange, grapefruit juice • Vegetables: 24 vegetables • French fried potatoes • Legumes JOURNAL OF THEAMERICAN DIETETICASSOCIATION Holt E, et al. J Am Diet Assoc. 2009; 109 (Mar).

  7. Fruit and Vegetable Consumption and its Relation to Markers of Inflammation and Oxidative Stress in Adolescents Statistical Methods • All analyses were conducted using SAS, version 9.1 • Variables with skewed distributions were log transformed to achieve normality; means were back transformed and reported as geometric means. • Spearman partial correlation analyses evaluated the relation of dietary intake with markers of inflammation and oxidative stress, adjusting for age, sex, race, Tanner stage, energy intake, and body mass index. JOURNAL OF THEAMERICAN DIETETICASSOCIATION Holt E, et al. J Am Diet Assoc. 2009; 109 (Mar).

  8. Fruit and Vegetable Consumption and its Relation to Markers of Inflammation and Oxidative Stress in Adolescents Results Mean (SD) physical and clinical characteristics of adolescent boys and girls, N=285 SD = standard deviation BMI = Body mass index JOURNAL OF THEAMERICAN DIETETICASSOCIATION Holt E, et al. J Am Diet Assoc. 2009; 109 (Mar).

  9. Fruit and Vegetable Consumption and its Relation to Markers of Inflammation and Oxidative Stress in Adolescents Mean (SD) markers of inflammation and oxidative stress among adolescent boys and girls, N=285 CRP = c-reactive protein TNF-a = Tumor necrosis factor-á IL-6 = Interleukin-6 F2-iso = F2-isoprostane PGF 2a = Prostaglandin F2a SD = standard deviation JOURNAL OF THEAMERICAN DIETETICASSOCIATION Holt E, et al. J Am Diet Assoc. 2009; 109 (Mar).

  10. Fruit and Vegetable Consumption and its Relation to Markers of Inflammation and Oxidative Stress in Adolescents Mean (SE) daily nutrient intake of adolescent 155 boys and 130 girls, N=285 aAdjusted for age, race, Tanner stage, energy intake b nutrients include food + supplement intake SE = standard error JOURNAL OF THEAMERICAN DIETETICASSOCIATION Holt E, et al. J Am Diet Assoc. 2009; 109 (Mar).

  11. Fruit and Vegetable Consumption and its Relation to Markers of Inflammation and Oxidative Stress in Adolescents Mean (SE) daily fruit and vegetable intake of adolescent 155 boys and 130 girls, N=285 aAdjusted for age, race, Tanner stage, energy intake bVegetables exclude french fries SE = standard error JOURNAL OF THEAMERICAN DIETETICASSOCIATION Holt E, et al. J Am Diet Assoc. 2009; 109 (Mar).

  12. Fruit and Vegetable Consumption and its Relation to Markers of Inflammation and Oxidative Stress in Adolescents Mean (SE) daily flavonoid intake of adolescent 155 boys and 130 girls, N=285 aAdjusted for age, race, Tanner stage, energy intake SE = standard error JOURNAL OF THEAMERICAN DIETETICASSOCIATION Holt E, et al. J Am Diet Assoc. 2009; 109 (Mar).

  13. Fruit and Vegetable Consumption and its Relation to Markers of Inflammation and Oxidative Stress in Adolescents Correlation of dietary antioxidants with markers of inflammation and Oxidative Stress in Adolescents, N=285 a = models adjusted for age, sex, race, Tanner stage, energy intake, Body Mass Index b= nutrients include food and vitamin supplement intake*p<0.05 CRP = c-reactive protein TNF-a = Tumor necrosis factor-á IL-6 = Interleukin-6 F2-iso = F2-isoprostane PGF 2a = Prostaglandin F2a JOURNAL OF THEAMERICAN DIETETICASSOCIATION Holt E, et al. J Am Diet Assoc. 2009; 109 (Mar).

  14. Fruit and Vegetable Consumption and its Relation to Markers of Inflammation and Oxidative Stress in Adolescents Correlation of food intake with markers of inflammation and oxidative stress in adolescents, N=285 *p<0.05 a = models adjusted for age, sex, race, Tanner stage, energy intake, Body Mass Index (BMI)b = total fruit and vegetables include fruit juice and French fried potatoes CRP = c-reactive protein TNF-a = Tumor necrosis factor-á IL-6 = Interleukin-6 F2-iso = F2-isoprostane PGF 2a = Prostaglandin F2a JOURNAL OF THEAMERICAN DIETETICASSOCIATION Holt E, et al. J Am Diet Assoc. 2009; 109 (Mar).

  15. Fruit and Vegetable Consumption and its Relation to Markers of Inflammation and Oxidative Stress in Adolescents Conclusions • The beneficial effects of fruit and vegetable intake on markers of inflammation and oxidative stress are already present by early adolescence. • These findings provide support for the United States Dietary Guideline “to consume five or more servings per day” of fruits and vegetables, which is beneficial for cardiovascular health. JOURNAL OF THEAMERICAN DIETETICASSOCIATION Holt E, et al. J Am Diet Assoc. 2009; 109 (Mar).

More Related