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Understanding the Role of Environmental Factors in Early Female Puberty and Breast Cancer

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caden
11 diapositives · 240 Views · Jul 16, 2014

The Breast Cancer and the Environment Research Center aims to investigate the determinants of early female puberty through a collaborative effort between federal and academic researchers. Funded jointly by NCI and NIEHS, the program seeks to establish a network of research centers, supported by advocacy groups. Over seven years, centers will explore how various environmental factors—such as diet, lifestyle, and endocrine disruptors—affect mammary gland development and pubertal timing, emphasizing teamwork and community engagement.

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  1. Breast Cancer and the Environment Research Center • Objective: understand determinants of early female puberty • Jointly funded by NCI and NIEHS • National BC Advocates lobbied Congress for $40 million to develop a network of research centers • 3 centers will be funded for 7 years each • Fund raising effort continue; more centers, longer funding, other type of grants Bob Bornschein 3-8-03

  2. What do we mean by environment? • It is an all inclusive term • Carcinogens; radiation, DDT, PAH, atrazine • Endocrine disruptors; PCBs, dioxin • Phytoestrogens; soy, isoflavones • Nutrition; lipids, PUFA, soy, dietary supplements • Lifestyle; stress, poverty, family structure • Internal hormonal environment; estrogens, growth regulating hormones, liver enzymes

  3. http://www.niehs.nih.gov/dert/programs/breastenv.htm

  4. Key Components of the Program • Partnership between Federal researchers (NCI & NIEHS) and academic researchers • Partnerships with breast cancer advocacy groups • Collaborations across 3 centers; common protocols and data sharing • Integration of individual ideas into collaborative projects across centers • Committees will set milestones yearly and then assess progress • Seven year program period; $900,000 per year • First year is dedicated to planning

  5. Partnerships • There must be a solid partnership between scientists and members of the breast cancer advocacy community in each Center. • Teamwork is required • Developing the proposal • Communication on issues related to all of the research • Translation of findings to the interested community, public at large and policy makers in many arenas • The role of the breast cancer advocacy community is formalized in two places • Community Outreach and Translation Core • Placement of consumers on the steering committee, and the research subcommittees to ensure their voice is heard

  6. 4 Components of a Center Sue Collaborative Project I Effects of Environmental Exposures on the Molecular Architecture of the Mammary Gland over the Lifespan (animal studies) Frank Collaborative Project II Environmental and Genetic Determinants of Puberty (children) Sue & Bob Administrative Core Katie Community Outreach and Education Core

  7. Multidisciplinary Teams • Collaborative Project 1 (animal) • Mammary gland biology, pathology, molecular biology, toxicology, genomics • Collaborative Project 2 (human) • Epidemiology, exposure assessment, biostatistics, pediatrics, endocrinology, genetics • Community Outreach and Translation Core • Breast cancer advocacy, community groups, health educators

  8. Breast Cancer and Environment Task Force • Federal scientists from NCI and NIEHS • National Advisory Environmental Health Sciences Council Members • Review progress • Coordinate Federal resources • Non-voting members of the National Steering Committee

  9. National Steering Committee Center Director, COTC Director * National BC Advocates BC&E Task Force Breast Biology Subcommittee PI 2 Co-investigators 2 Members of COTC Epidemiology Subcommittee PI 2 Co-investigators 2 Members of COTC ** ** *One meeting per year ** Four meetings in year one, later years, as needed