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NIH/NASA Meeting on Space-Related Health Research

NIH/NASA Meeting on Space-Related Health Research. Henry Rodriguez, Ph.D., M.B.A. Director, Clinical Proteomic Technologies Initiative National Cancer Institute. December 8, 2006. Technology Benefits. Technology Benefits to NCI. Bio-Technology Benefits to NASA.

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NIH/NASA Meeting on Space-Related Health Research

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  1. NIH/NASA Meeting onSpace-Related Health Research Henry Rodriguez, Ph.D., M.B.A. Director, Clinical Proteomic Technologies Initiative National Cancer Institute December 8, 2006

  2. Technology Benefits Technology Benefits to NCI Bio-Technology Benefits to NASA Miniaturized biochemical analytic laboratories Early detection Fabrication of ultra rugged materials and structures Accurate diagnosis Prevention and improved therapies Bio-Astronautics and Human Exploration

  3. Molecular Beacons (enabling live detection of gene expression) Ultra-bright contrast agent (deep tissue imaging, > 1 cm) Fundamental Technologies in Biomolecular Sensors (NCI-NASA) A Nanogel (carbohydrate or PEG nanoparticle – targeted drug delivery tool) • Workshop (June 1999) on Sensors for Bio-Molecular Signatures • Richard Klausner, Director NCI; Daniel Goldin, NASA Administrator • April 2000 MOU, Oct. 2000 launched • Total 6 awards, $13.6M over 4 yrs. • Launching companies & Building foundation for NCI Alliance for Nanotechnology in Cancer • Peptide Functionalized Nanoparticles (Alnis Biosciences Inc., collaboration with UNC Center of Cancer Nanotechnology Excellence) • Ultra-bright Near Infrared Fluorophores (possible synergy with Emory and MIT/Harvard Centers of Cancer Nanotechnology Excellence) • Molecular Beacons (PI became co-PI of MIT/Harvard Center of Cancer Nanotechnology Excellence) B C

  4. Object Oriented Data Technology(NCI-NASA/JPL) • OODT’s architecture originally developed for NASA’s planetary data system (PDS) project by JPL • Open source & Based on open standards: Java, XML, Web Services • Distributed network that is secure and confidential • EDRN’s Virtual Specimen distributed query system (ERNE) is based on NASA’s OODT • Existing sites specimen databases maintained locally • Uses EDRN Common Data Elements (CDEs) • OODT Framework includes: • Name Server; Query Server; Archive Server; Profile Server; Product Server; Server Manager

  5. Nanowire arrays for early detection (NCI/NASA-Goddard/U. Maryland) • Controlled on-chip synthesis (SiNWs and carbon nanotubes) • Surface mod. readily achieved for affinity-capture material • Ultra-sensitive and fast sensors for electrical, real-time and label-free detection sensing of chemical or biological species (amplicon - femtomolar) • Nucleic acid sequence detection, protein marker detection, and single viral particle detection Nanomedicine (2006) 1(1), 51-65 Nature Protocols (2006) 1(4), 1711-1724

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