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Current Areas of Space-Related Health Research

The Effect of Microgravity on Calcium Metabolism and Bone Formation in Chick Embryo 1992 NASA SPACE SHUTTLE MISSION SPACELAB JSTS-47 PI: Tatsuo Suda (Showa University). COLUMBIA ST-48. Current Areas of Space-Related Health Research. Skeletal Tissue Engineering

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Current Areas of Space-Related Health Research

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  1. The Effect of Microgravity on Calcium Metabolism and Bone Formation in Chick Embryo 1992 NASA SPACE SHUTTLE MISSION SPACELAB JSTS-47 PI: Tatsuo Suda (Showa University) COLUMBIA ST-48 Current Areas of Space-Related Health Research • Skeletal Tissue Engineering - Adult mesenchymal stem cells - Nanobiomaterial scaffold - Bioreactor requirement Presenter: Rocky S. Tuan, Ph.D., Chief, Cartilage Biology and Orthopaedics Branch Agency/Organization: NIAMS, NIH, DHHS

  2. Polymer Solution (a-Hydroxy Polyester) Voltage Source Electrospun nanofibers V 18 kV With seeded cells Polymer Cloud Seeded cells stained for cytoskeleton Ground Application of Electrospun Nanofibrous Scaffold for Cell-Based Tissue Engineering

  3. Dynamic Culture Promotes Tissue Integration Tissue-Engineered Cartilage Using Nanofibrous Scaffold, Human Adult Stem Cells, TGF-b, and Bioreactor

  4. Promising Areas for Space-Related Health Research Collaborations • Understand the mechanisms responsible for randomized gravity mediated enhancement of stem cell-based cartilage formation • Design novel bioreactors based on microgravity related principles for improved tissue engineering applications.

  5. Existing Resources to Facilitate Space-Related Health Research Cartilage Biology and Orthopaedics Branch NIAMS, NIH • Human resources - a unique consortium of biologists, engineers and surgeons • Physical resources - instrumentation design and prototyping, mechanoactive bioreactors, biomaterial scaffold production, adult stem cell technologies, mechanical testing

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