1 / 5

Current Areas of Space-Related Health Research

This presentation explores the effects of microgravity on calcium metabolism and bone formation, highlighting findings from a 1992 NASA Space Shuttle mission involving chick embryos. It discusses advanced tissue engineering approaches utilizing adult mesenchymal stem cells and nanobiomaterial scaffolds, emphasizing how dynamic culture and bioreactors can enhance cartilage formation. Key areas of research include understanding stem cell mechanisms under randomized gravity conditions and designing innovative bioreactors for better tissue engineering outcomes. Collaborative efforts leverage unique human and physical resources to advance space-related health research.

barton
Télécharger la présentation

Current Areas of Space-Related Health Research

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. The Effect of Microgravity on Calcium Metabolism and Bone Formation in Chick Embryo 1992 NASA SPACE SHUTTLE MISSION SPACELAB JSTS-47 PI: Tatsuo Suda (Showa University) COLUMBIA ST-48 Current Areas of Space-Related Health Research • Skeletal Tissue Engineering - Adult mesenchymal stem cells - Nanobiomaterial scaffold - Bioreactor requirement Presenter: Rocky S. Tuan, Ph.D., Chief, Cartilage Biology and Orthopaedics Branch Agency/Organization: NIAMS, NIH, DHHS

  2. Polymer Solution (a-Hydroxy Polyester) Voltage Source Electrospun nanofibers V 18 kV With seeded cells Polymer Cloud Seeded cells stained for cytoskeleton Ground Application of Electrospun Nanofibrous Scaffold for Cell-Based Tissue Engineering

  3. Dynamic Culture Promotes Tissue Integration Tissue-Engineered Cartilage Using Nanofibrous Scaffold, Human Adult Stem Cells, TGF-b, and Bioreactor

  4. Promising Areas for Space-Related Health Research Collaborations • Understand the mechanisms responsible for randomized gravity mediated enhancement of stem cell-based cartilage formation • Design novel bioreactors based on microgravity related principles for improved tissue engineering applications.

  5. Existing Resources to Facilitate Space-Related Health Research Cartilage Biology and Orthopaedics Branch NIAMS, NIH • Human resources - a unique consortium of biologists, engineers and surgeons • Physical resources - instrumentation design and prototyping, mechanoactive bioreactors, biomaterial scaffold production, adult stem cell technologies, mechanical testing

More Related