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1. Ibogaine (brief review) 2. Ibogaine Development

Introduction to Presentation by HS Lotsof. 1. Ibogaine (brief review) 2. Ibogaine Development. 2006 NYC Ibogaine Conference Columbia University Saturday, February 25. Ibogaine Found in a West African plant Tabernanthe iboga. T. Iboga is Valued for its roots.

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1. Ibogaine (brief review) 2. Ibogaine Development

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  1. Introduction to Presentation by HS Lotsof 1. Ibogaine(brief review)2. Ibogaine Development 2006 NYC Ibogaine Conference Columbia University Saturday, February 25

  2. Ibogaine Found in a West African plant Tabernanthe iboga

  3. T. Iboga is Valued for its roots

  4. Iboga alkaloids are concentrated in the bark of the root

  5. Usable forms include scraped or ground root bark

  6. Total Alkaloid extract Courtesy Sara Glatt

  7. Purified Chemical Proposed as an approved regulated drug

  8. Physical Characteristics of ibogaine baseSource Merck Index Chemical formula C20H26N2O Mol. Wt. 310.42 Melting Point 152-153° Practically insoluble in water. Soluble in ethanol, ether, chloroform Molecular structure

  9. Ibogaine Development or Lack Thereof: Politics Policy Prejudice Profit Science Howard S. Lotsof Dora Weiner Foundation http://www.doraweiner.org

  10. The activities within a government or agency or other human endeavor that may include debate and conflict. Politics Prohibition Legalization or Regulation War on Drugs War on Some Drugs War on Drug Users

  11. Drug Politics may be top down from government agencies such as the ONDCP

  12. DEA

  13. FDA

  14. Drug Politics are also bottom up from grassroots organizations such as the SSDP

  15. Harm Reduction Coalition

  16. Cures Not Wars

  17. Precedents for Ibogaine Activist Organizations • International Coalition for Addict Self-Help (ICASH) • Dutch Addict Self-Help (DASH) • Cures-Not Wars (ibogaine and other issues) • Ibogaine Underground

  18. ICASH logo Used to attract attention of government officials and media

  19. Nico Adriaans was one of the founders of both the Rotterdam Junkies Union and Dutch Addict Self-Help (DASH). DASH was an ibogaine self-help organization that petitioned the Dutch government and organized drug users to demand ibogaine availability. DASH provided ibogaine at no cost to heroin users.

  20. ICASH Organizing in the US

  21. Cures-Not-Wars placed pressure on NIDA to support Ibogaine research through protests

  22. Mindvox Ibogaine List(user advocacy continues) “We all got to help each other best we can. No one else gives a shit ‘bout us hippy freak junkies? ” anon. To join send an email to ibogaine-subscribe@mindvox.com

  23. “FM- I'm not really privy to what's happening in that regard here in the US. Suffice to say, nothing has worked which is why we're here. We feel that continuing the focus offshore, outside the US, has not served a majority of people inside the US. Like many other grassroots movement, which facilitated change, treatments, sessions, need to be done where they belong, in all major US cities, as cost effectively as possible. “http://www.drugwar.com/ibonyc.shtm Ibogaine underground appears 2004

  24. A course or principle of action adopted or proposed by a government, party, business, or individual Policy Harm Reduction Demand Reduction How Ibogaine is Viewed

  25. Ibogaine represents both harm reduction and demand reduction DEA desk officer in the Netherlands asks how the Dutch are allowing a demand reduction drug like ibogaine to be researched in the Netherlands? Ibogaine proponents view the drug as significant harm reduction tool and basis for political action.

  26. Prejudice A generally negative preconceived opinion that is not based on reason or actual experience

  27. Discrimination Prejudice incorporates The unjust or prejudicial treatment of different categories of people or things. Stigma A mark of disgrace associated with a particular circumstance, quality, or person : the stigma of chemical dependence.

  28. Discrimination Focuses attention on those who produce rejection and exclusion

  29. Stigma Focuses attention on the victim

  30. Prejudice, stigma and discrimination, in part, determine what drugs will be regulated, what drugs will not be regulated and what medications will be or not be made available to treat chemical dependence

  31. Ibogaine Effects on Stigma Ibogaine is reported to have the ability to remove the stigmatized condition, transforming the patient to a state often described as a preaddictive.

  32. The transformation of a stigmatized person into one who is not stigmatized will have significant effects on the person and the society within which the individual lives as it allows for personal growth and the possibility of a greater contribution to society. This dynamic is expressed within the activities of the ibogaine advocacy movement in the services they offer to chemically dependent persons and the political actions taken to promote ibogaine availability. Additional Ibogaine Effects on Stigma

  33. A financial gain, The difference between the amount earned and the amount spent in buying, operating, or producing something : | their eyes brightened at the prospect of profit. Profit Politics Policy Prejudice Science

  34. Profit is a core issue in the pharmaceutical industry whose primary purpose is to return profit to corporate shareholders. This effects what drugs will be developed and the areas of medicine for which drugs will be available.

  35. The intellectual and practical activity encompassing the systematic study of the structure and behavior of the physical and natural world through observation and experiment Science Politics Policy Prejudice Profit Intellectual Conformity

  36. National Institute on Drug Abuse (NIDA) funds 85% of drug addiction research worldwide

  37. NIDA was petitioned to perform ibogaine research 1984 - 1990, first by the Dora Weiner Foundation and from 1986 on by NDA International, Inc., a company established to make ibogaine available as an approved medication. In 1991, NIDA formed its Medications Development Division (MDD) and accepted a Product Profile Review (PPR) from NDA International that resulted in NIDA starting their ibogaine research program. NIDA Initially Rejects Ibogaine Research.

  38. The following are examples demonstrating the scientific contention between NIDA and pro-ibogaine researchers that played out between 1988 and 2000.

  39. First scientific publication of ibogaine antiaddictive effects

  40. NIDA Response: It doesn’t work

  41. Ibogaine Scientists Answer

  42. NIDA contracts neurotoxicologist Mark Molliver to determine ibogaine neurotoxicity

  43. Ibogaine researcher Helen Molinari responded

  44. Further research by O’Hearn and Molliver

  45. Xu et al. eventually produce research showing no neurotoxicity at clinical doses(2000)

  46. Xu et al. accomplished research in part at the National Center for Toxicological Research an FDA laboratory.The research demonstrated no neurotoxicity at 25 mg/kg.

  47. Ibogaine science continues to grow providing 100s of peer reviewed papers

  48. A few key papers relating to ibogaine research and second generation ibogaine-like drugs to treat chemical dependence follow. These include ibogaine effects on opioid narcotics.

  49. Ibogaine effects on cocaine

  50. Ibogaine effects on alcohol

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