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Folding DNA to create nanoscale shapes and patterns

Folding DNA to create nanoscale shapes and patterns. Author: Paul Rothemund. Motivation. “Writing the Encyclopedia Britannica on the head of a pin” --Richard Feynman, 1959 Why not use AFM and STM?. Slow, and require special conditions. DNA Origami.

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Folding DNA to create nanoscale shapes and patterns

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  1. Folding DNA to create nanoscale shapes and patterns Author: Paul Rothemund

  2. Motivation • “Writing the Encyclopedia Britannica on the head of a pin” --Richard Feynman, 1959 • Why not use AFM and STM? Slow, and require special conditions

  3. DNA Origami Watson-Crick base pairing allows for inexpensive parallel synthesis, under mild conditions (!)

  4. Synthesis

  5. Synthesis

  6. Synthesis

  7. Selected Interesting Shapes

  8. AFM Imaging Methodology • Probably contact mode AFM • Problems: destructive, difficult to quantify small defects (<15nm)

  9. AFM Imaging Methodology

  10. AFM Imaging Methodology • Probably contact mode AFM • Problem: destructive

  11. Results

  12. DNA Origami Patterning

  13. Applications Nano-breadboards Attach nanowires Attach proteins

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