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Understanding Sir2, Sum1, and Hst1 Interactions in Yeast Promoter Regions

This study explores the relationship among Sir2, Sum1, and Hst1 proteins within the promoter regions of yeast genes. It delves into their binding at specific locations like inside ORFs or intergenic regions, peak binding sites, and regions near the 3’ end of ORFs. The analysis also considers the distribution of tags associated with Sir2, Sum1, and Hst1, shedding light on their functional roles.

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Understanding Sir2, Sum1, and Hst1 Interactions in Yeast Promoter Regions

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  1. (a) Sir2 Sum1 Hst1 Promoter ORF ORF inside peak 3’ end of ORF Intergenic (b) (c) 100 70 Sir2 Hst1 60 80 50 60 # of Tags 40 ** 40 Sir2 Hst1 22 30 28 153 20 20 ** 29 ** ** 20 Sum1 Hst2 26 4 80 70 15 Sum1 60 18 10 # of Tags 50 40 5 30 0 (d) ENO2 PDC1 CDC19 500 bp 500 bp 500 bp [0- 1093] Input [0- 666] Sir2 [0- 500] Hst1 [0- 565] Sum1 [0- 84] Hst2 YHR176W YHR175W YHR174W YHR172W YAL037C-A YAL037W YAL038W YLR040C YLR043C YLR044C YLR045C (e) PDC1 ENO2 Relative IP 5’ end middle 3’ end 5’ end middle 3’ end

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