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Centers for Disease Control and Prevention (CDC): Roles and Mission

Centers for Disease Control and Prevention (CDC): Roles and Mission

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Centers for Disease Control and Prevention (CDC): Roles and Mission

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  1. Centers for Disease Control and Prevention (CDC): Roles and Mission D. Joe Boone, Ph.D. Atlanta, Georgia February 23, 2010 National Defense Industrial Association Georgia Chapter Luncheon

  2. CDC’s Mission • To promote health and quality of life by preventing and controlling disease, injury, and disability • Works with partners throughout the nation and the world to: • Monitor health • Detect, investigate health problems • Conduct research to enhance prevention • Develop, advocate sound public health policies • Implement prevention strategies • Promote healthy behaviors • Foster safe and healthful environments • Provide leadership and training

  3. CDC Organizational Chart

  4. Centers for Disease Control and Prevention (CDC) CDC’s 2010 budget is ~$10.1B : • Nearly 85 percent goes to extramural grants and contracts to help accomplish the mission to promote health and quality of life by preventing and controlling disease, injury, and disability. • The majority of these go to state and local governments. • Received $1B in ARRA funding almost all targeted for state and local governments.

  5. CDC Budget 1997-2009

  6. FY 2010 CDC Programs with Proposed Increases • HIV/AIDS, Domestic Testing Initiative (+$51.0M) • Strategic National Stockpile (+25.2M) • Public Health Emergency Preparedness (+$14.2M) • Health Statistics (+$13.2M) • Emerging Infectious Disease (+$10.0M) • Global Immunization Program (+$10.0M) • School Health (+$5.0M) • Safe Motherhood/Infant Health(+$5.0M) • Nanotechnology (+$5.0M) - NIOSH • Food Safety (+$4.0M) • Domestic Violence (+$3.0M) • Navajo Nation Uranium Studies (+$2.0M) • Paralysis Resource Center(+$2.0M) • Autism (+$1.6M)

  7. CDC’s Role in National Defense • Emergency Preparedness • Prepares for staff deployment • Conducts laboratory applied research • Recommends prevention measures, public health policies • Conducts surveillance • Manages Laboratory Response Network (LRN) • Conducts program evaluations • Partners liaisons/relationships • Emergency Response • Provides on-scene support • Provides Strategic National Stockpile (SNS) • Conducts investigations • Provides laboratory analyses and support

  8. Office of Public Health Preparedness • Helps nation prepare and respond to public health threats by providing strategic direction, support, and coordination across CDC and with state and local health departments. • Receives about $1B from Congress for response to natural, biological, chemical, radiological, and nuclear incidents. • Funding Guidance and Technical Assistance to States • Strategic National Stockpile • CDC Emergency Operations Center • Regulation of Select Agents • Science and Public Health Practice

  9. Laboratory Applied Research • Pandemic Influenza H1N1 • Surveillance for pandemic strains (Avian H5N1; 1918 Spanish Influenza) • Rapid methods to distinguish pandemic versus seasonal flu • Available to doctor’s offices • Vaccine development • Prevention of pandemic flu • Anti-viral medications

  10. Vaccine Development - Smallpox • Smallpox is potential terrorist threat • Younger population unvaccinated • CDC sought smallpox vaccine for the Strategic National Stockpile • CDC partnered to develop smallpox therapeutic products • live virus vaccine • Vaccinia Immune Globulin • FDA License granted 2007 for smallpox vaccine

  11. Laboratory Response Network (LRN) • Network of 150 Federal, State, local public health, & military laboratories that respond quickly to: • Chemical & biological terrorism • Emerging infectious diseases • Health threats • Emergencies • Level 3, 2, 1 labs • Responses • Anthrax attacks 2001 • Avian influenza • Severe Acute Respiratory Syndrome (SARS) • Biowatch

  12. Laboratory Methods – Exposure Assessment • Biomonitoring • Directly measures chemicals or their metabolites in biological specimens • Detects/confirms exposure to chemicals or their metabolites • Estimates extent/magnitude of exposure in persons or population • Important decision making tool in suspected terrorist events for • Public health officials • Military • Law enforcement officials

  13. Hypothetical Concentrations of Biomonitoring Products Over Time Blood Toxicant/Metabolite Urinary Metabolite If a chemical forms an adduct, its time window to assess exposure will be extended. Albumin Adduct Concentration HemoglobinAdduct DNA Adduct Urinary Adduct 1 10 100 1000 Time (Days) Needham and Sexton, JEAEE 10:611-629 (2000)

  14. Biomonitoring for HD – Sulfur Mustard • Mass spectrometry • Used biomonitoring methods to measure actual exposure to HD • 2 patients accidentally exposed • SBMTE found days 1-6 in both patients • Found albumin – HD adducts for biomonitoring • Adduct ½ life in patient = 21 days • Still detectable at 42 days

  15. Battelle: Known For Innovation Xerox • Energy, National Security, Health and Life Sciences, National Lab Mgmt are Core Businesses • Winner of 117 R&D 100 Awards • Over 350 patents issued for Battelle technology since 2001 • 38 Technology Groups ranging from Electrical Engineering to Advanced Materials to Information Technology to Photonics to Pollution Prevention Computer-BasedRobot Trainer Sonic Toothbrush Drug Inhaler “Heat Seat” Compact Disk

  16. Major Battelle Centers Battelle Eastern Science and Technology Center Aberdeen,Maryland May 2007 Battelle Ocean Sciences Duxbury, Massachusetts Dec 2006 Battelle Marine Sciences Sequim, Washington Lawrence Livermore National Laboratory Livermore, California National Biodefense Analysis and Countermeasures Center Ft. Detrick, Maryland Brookhaven National Laboratory Long Island, New York Pacific Northwest National Laboratory Richland, Washington Corporate Headquarters Columbus, Ohio Oak Ridge National Laboratory Oak Ridge, Tennessee National Renewable Energy Laboratory Golden, Colorado Idaho National Laboratory Idaho Falls, Idaho

  17. Thank youQuestions?