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Pituitary disease

Pituitary disease. Hyperfunction: arises because of an actively secreting adenoma or a hypothalamic tumour inducing hypersecretion Hypofunction: results from destruction of normal tissue by an adenoma or other mass lesion, an infarct, or following surgical or radiation therapy.

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Pituitary disease

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  1. Pituitary disease • Hyperfunction: arises because of an actively secreting adenoma or a hypothalamic tumour inducing hypersecretion • Hypofunction: results from destruction of normal tissue by an adenoma or other mass lesion, an infarct, or following surgical or radiation therapy

  2. Effects of pituitary adenomas • hypersecretion of one or more hormones • prolactin 30% • ACTH 15% • growth hormone 15% • growth hormone + prolactin 10% • FSH + LH (low levels) 15% • mass effects • reduced secretion of other anterior pituitary hormones • diabetes insipidus • visual disturbances • headaches • signs of raised intracranial pressure

  3. Magnetic resonance image of a pituitary adenoma

  4. Macroscopic and microscopic appearance of a pituitary adenoma Images from WebPath

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