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Effective Execution of Your in vivo Pharmacology Research by using CROs

Effective Execution of Your in vivo Pharmacology Research by using CROs. Target identification. Target validation. In vitro compound screening. In vivo efficacy. Pharmacology. Toxicology. IND. Nature of in vivo pharmacology research. High start up cost Facility Equipment

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Effective Execution of Your in vivo Pharmacology Research by using CROs

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  1. Effective Execution of Your in vivo Pharmacology Research by using CROs

  2. Target identification Target validation In vitro compound screening In vivo efficacy Pharmacology Toxicology IND

  3. Nature of in vivo pharmacology research • High start up cost • Facility • Equipment • Personnel • High regulatory burden • Long start up time • High maintenance cost • Personnel-centric • “Low tech” • Routine

  4. Different levels of outsourcing • Contract Personnel • Contract Facility/incubator • Contract Research (outsourcing)

  5. Example : contract research 10 studies using a cancer xenograft model

  6. Example: off-site vivarium Room 1: 100 cages of mice Room 2: 50 cages of rats HEPA-filtered ventilated caging

  7. Keys to successful outsourcing • Due diligence • Facility • Management system • Personnel • Project management • Plan ahead • Define clear project goals • Communication management

  8. Effective Execution of Your in vivo Pharmacology Research by using CROs

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